Results 81 to 90 of about 5,170,261 (242)

Mixed Mode Oscillation in FitzHugh-Rinzel Model

پژوهش‌های ریاضی, 2021
FitzHugh-Nagumo-Rinzel model is an important model for the dynamics of single neuron. We observed some patterns of Bursting specially Mixed Mode Oscillation (MMO) in this model.
Mohammad Reza Razvan, Seyed Sheida Shahidi Shadkam   +1 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Single VDCC-Based Mixed-Mode First-Order Universal Filter and Applications in Bio-Signal Processing Systems

Technologies
This paper presents a compact mixed-mode first-order universal filter based on a single voltage differencing current conveyor (VDCC), which can function in all four possible operation modes, i.e., voltage mode (VM), trans-admittance mode (TAM), current ...
Pitchayanin Moonmuang, Natchanai Roongmuanpha, Worapong Tangsrirat, Tattaya Pukkalanun   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Investigation of crack growth behaviour under mixed mode loading [PDF]

, 2006
The crack growth resistance of different metals under mixed mode (I+II) and biaxial loading was investigated. Fracture pattern depends on the load ratio under different modes and their level.
Покровский, В. В., Pokrovsky, V. V., Koval, Yu. I., Коваль, Ю. И., Sydiachenko, V. G., Ежов, В. Н., Сидяченко, В. Г., Yezhov, V. N.   +7 more
core   +1 more source

Does Including Internet Users in the Mail Mode Improve the Data Quality of a Probability-Based Mixed-Mode Panel?

Survey Research Methods
Previous research on probability-based online panels shows that providing the offline-population with an alternative survey mode reduces coverage bias.
David Bretschi, Jessica Daikeler, Anna Neumann   +2 more
doaj   +1 more source

A randomised trial and economic evaluation of the effect of response mode on response rate, response bias, and item non-response in a survey of doctors

BMC Medical Research Methodology, 2011
Background Surveys of doctors are an important data collection method in health services research. Ways to improve response rates, minimise survey response bias and item non-response, within a given budget, have not previously been addressed in the same ...
Witt Julia, Kalb Guyonne, Humphreys John S, Joyce Catherine M, Jeon Sung-Hee, Scott Anthony, Leahy Anne   +6 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source