Results 221 to 230 of about 4,947,794 (321)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Recent Advances in the Enantiomeric Separation of Tropane Alkaloids by Liquid Chromatography: Analytical Strategies and Applications in Pharmaceutical, Biological, and Food Samples. [PDF]

Toxins (Basel)
Vera-Baquero FL, González-Gómez L, Sierra I, Morante-Zarcero S.   +3 more
europepmc   +1 more source

Rapid Exonuclease‐Based De Novo Sequencing Strategy for Long Oligonucleotides via Liquid‐Phase Ion Trap Coupled With Mass Spectrometry

Advanced Science, EarlyView.
A liquid‐phase ion trap (LPIT) coupled with ESI‐MS enables rapid, high‐fidelity de novo sequencing of long oligonucleotides in ∼30 min. By applying an electric field to dissociate metal adducts in solution, LPIT delivers clean spectra, superior mass accuracy, and full sequence coverage, surpassing MALDI‐TOF and LC‐MS.
Song Lu, Jie Hong, Xinyan Fu, Di Wang, Yunhua Gao, Wei Xu   +5 more
wiley   +1 more source

Column switching liquid chromatography dual mass spectrometry system for simultaneous untargeted metabolomics and targeted exposomics. [PDF]

Nat Commun
Wang Y, Hou D, Yuan Y, Guan P, Chen T, Guo X, You X, Shi X, Wang X, Wang Q, Liu X, Xu G.   +11 more
europepmc   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Bioactivity-Guided Identification of Ethyl Gallate from Pecan (<i>Carya illinoinensis</i>) and Its Protective Effects Against Oxidative Stress and Amyloid-β-Induced Cognitive Impairment. [PDF]

Foods
Park CK, Shin DH.
europepmc   +1 more source

Lipidomic Profiling of Commercial <i>Hydnocarpus wightianus</i> Oil by UPLC-QTOF-MS/MS and GC-MS: Degradation-Associated Lipid Classes as Candidate Quality Attributes for a Non-Pharmacopoeial Excipient. [PDF]

Molecules
Balwierz R, Schäfer N, Kuropka P, Wiśniewski J, Wieczorek D, Biernat P, Lipok J.   +6 more
europepmc   +1 more source

High-throughput monitoring of in vitro enzymatic reactions using probe electrospray ionization-mass spectrometry. [PDF]

Anal Bioanal Chem
Okahashi N, Taniguchi T, Suzuki T, Hattori T, Takahashi H, Honda K, Matsuda F.   +6 more
europepmc   +1 more source

Enhanced Antioxidant and ACE-Inhibitory Activities of L-Theanine Following Formation of the Amadori Compound N-(1-Deoxy-D-Fructose-1-yl)-L-Theanine (Fru-The). [PDF]

Foods
Li F, Zhou J, Zhang M, Zhang G, Sun W, Ge H, Zhou R.   +6 more
europepmc   +1 more source

Mixed-Mode Chromatography to Mitigate Diluent-Eluent Mismatch

, 2021
openaire   +1 more source