Results 111 to 120 of about 5,107,925 (306)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
An Analogue and Mixed-Signal Extension to SystemC
, 2005 This paper presents a new methodology that enables extensions of SystemC to the analogue domain and allows modelling of mixed-signal and mixed energy-domain systems at arbitrary levels of abstraction.
Kazmierski, Tom, Al-Junaid, Hessa
core +1 more source
IEEE Open Journal of Circuits and SystemsThis paper presents a bandgap voltage reference (BGR) circuit with a wide supply voltage and temperature range, suitable for automotive applications.
U Chi-Wa +4 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
An Overview of Hybrid DC–DC Converters: From Seeds to Leaves
IEEE Open Journal of the Solid-State Circuits SocietyWith the surging demands for higher current at sub-1-V supply level in high-performance digital systems, high-efficiency and high-current-density power converters are essential for system integration.
Yan Lu +7 more
doaj +1 more source
AIP Advances, 2014 Digital Microfluidics (DMF) is a promising technology for biological/chemical micro-reactions due to its distinct droplet manageability via electronic automation, but the limited velocity of droplet transportation has hindered DMF from utilization in ...
Tianlan Chen +6 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ecology and EvolutionUnderstanding the mechanisms driving aboveground biomass (AGB) variation in forest ecosystems is essential for biodiversity conservation and climate‐change mitigation, particularly in environmentally heterogeneous and resource‐limited regions. Drawing on
Shahab Ali +3 more
doaj +1 more source