Results 131 to 140 of about 7,760,731 (337)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
A Mixed-Methods Study of the Effect of Using Situation Comedies on Iranian EFL Learners’ Critical Reasoning and Action [PDF]
Journal of Language HorizonsThis mixed-methods study, adopting a sequential explanatory design, aimed to (a) investigate the effect of situation comedies (sitcoms) on Iranian EFL learners’ critical reasoning as well as action and (b) explore learners’ attitudes about the way ...
zeinab Mohammadian +2 more
doaj +1 more source
Chaos at the border of criticality
, 2008 The present paper points out to a novel scenario for formation of chaotic attractors in a class of models of excitable cell membranes near an Andronov-Hopf bifurcation (AHB).
Brøns M. +4 more
core +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Development Cost Optimization for Multi-Functional Mixed-Criticality Embedded Systems
IEEE Access, 2019 In some industrial embedded systems, functions with different safety integrity levels (SILs) are integrated into the same hardware platform to share resources, and usually, the schedulability of applications should be met first.
Yehua Wei +3 more
doaj +1 more source
GSN Support of Mixed-Criticality Systems Certification [PDF]
, 2017 Safety-critical applications could benefit from the standardisation, cost reduction and cross-domain suitability of current heterogeneous computing platforms. They are of particular interest for Mixed-Criticality Product Lines (MCPL) where safety- and non-safety functions can be deployed on a single embedded device using suitable isolation artefacts ...
Carlos-Fernando, Nicolas +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Modeling Mixed-critical Systems in Real-time BIP
, 2013 International audienceThe proliferation of multi- and manycores creates an important design problem: the design and verification for mixed-criticality constraints in timing and safety, taking into account the resource sharing and hardware faults.
Bensalem, Saddek +3 more
core +1 more source