Results 121 to 130 of about 7,760,731 (337)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Hypervisor-Based Multicore Feedback Control of Mixed-Criticality Systems

IEEE Access, 2018
One of the most promising approaches to mixed-criticality systems is the use of multi-core execution platforms based on a hypervisor. Several successful EU Projects are based on this approach and have overcome some of the difficulties that this approach ...
Alfons Crespo, Patricia Balbastre, Jose Simo, Javier Coronel, Daniel Gracia-Perez, Philippe Bonnot   +5 more
doaj   +1 more source

Density of defects and the scaling law of the entanglement entropy in quantum phase transition of one dimensional spin systems induced by a quench

, 2011
We have studied quantum phase transition induced by a quench in different one dimensional spin systems. Our analysis is based on the dynamical mechanism which envisages nonadiabaticity in the vicinity of the critical point.
Banasri Basu, J. Gonzalez, J. I. Latorre, L. D. Landau, Pratul Bandyopadhyay, Priyadarshi Majumdar   +5 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Experimental Evaluation of SAFEPOWER Architecture for Safe and Power-Efficient Mixed-Criticality Systems

Journal of Low Power Electronics and Applications, 2019
With the ever-increasing industrial demand for bigger, faster and more efficient systems, a growing number of cores is integrated on a single chip. Additionally, their performance is further maximized by simultaneously executing as many processes as ...
Maher Fakih, Kim Grüttner, Sören Schreiner, Razi Seyyedi, Mikel Azkarate-Askasua, Peio Onaindia, Tomaso Poggi, Nera González Romero, Elena Quesada Gonzalez, Timmy Sundström, Salvador Peiró Frasquet, Patricia Balbastre, Tage Mohammadat, Johnny Öberg, Yosab Bebawy, Roman Obermaisser, Adele Maleki, Alina Lenz, Duncan Graham   +18 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Decoupling Criticality and Importance in Mixed-Criticality Scheduling [PDF]

, 2018
Research on mixed-criticality scheduling has flourished since Vestal’s seminal 2007 paper, but more efforts are needed in order to make these results more suitable for industrial adoption and robust and versatile enough to influence the evolution of future certification standards in keeping up with the times.
Bletsas, Konstantinos, Ali Awan, Muhammad, Souto, Pedro, Åkesson, Benny, Burns, Alan, Tovar, Eduardo   +5 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Enhancing Performance in Mixed‐Criticality Real‐Time Systems Through Learner‐Based Resource Management

IET Cyber-Physical Systems
In mixed‐criticality (MC) systems, tasks with varying criticality levels share resources, leading to challenges in resource management during mode transitions.
Mohammadreza Saberikia, Hakem Beitollahi, Rasool Jader, Hamed Farbeh   +3 more
doaj   +1 more source

Decay of Loschmidt Echo Enhanced by Quantum Criticality

, 2006
We study the transition of a quantum system $S $ from a pure state to a mixed one, which is induced by the quantum criticality of the surrounding system $E$ coupled to it.
A. Peres, C. P. Sun, C. P. Sun, C. P. Sun, C. P. Sun, E. Joos, H. T. Quan, J. S. Bell, K. Hepp, M. Cini, P. Zanardi, S. Haroche, S. Sachdev, W. H. Zurek, X. F. Liu, Z. Song   +15 more
core   +1 more source