Results 101 to 110 of about 1,976,702 (277)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Development of Real-Time and Mixed Criticality Distributed Systems through the DDS Standard
Revista Iberoamericana de Automática e Informática Industrial RIAI, 2018 The use of distribution middleware facilitates the programming of heterogeneous real-time distributed systems, and it can also facilitate the automatic generation of source code when integrated as a part of a general MDE (Model-Driven Engineering ...
Héctor Pérez Tijero +1 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Hypervisor-Based Multicore Feedback Control of Mixed-Criticality Systems
IEEE Access, 2018 One of the most promising approaches to mixed-criticality systems is the use of multi-core execution platforms based on a hypervisor. Several successful EU Projects are based on this approach and have overcome some of the difficulties that this approach ...
Alfons Crespo +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Mastering MPSoCs for Mixed-critical Applications
IPSJ Transactions on System LSI Design Methodology, 2011 Multi-Processor Systems-on-Chips (MPSoCs) emerge as the predominant platform in embedded real-time applications. A large variety of ubiquitous services should be implemented by embedded systems in a cost- and power-efficient way, yet providing a maximum degree of performance, usability and dependability.
Axer, Philip +5 more
openaire +3 more sources
Journal of Low Power Electronics and Applications, 2019 With the ever-increasing industrial demand for bigger, faster and more efficient systems, a growing number of cores is integrated on a single chip. Additionally, their performance is further maximized by simultaneously executing as many processes as ...
Maher Fakih +18 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Engineering mixed-criticality interactive applications
Proceedings of the 8th ACM SIGCHI Symposium on Engineering Interactive Computing Systems, 2016 In the field of critical systems, safety standards such as DO-178C define Development Assurance Levels (DALs) for software systems (or sub-systems). The higher the consequence of a failure the higher DAL is required by certification authorities. Developing a system at a DAL A requires the use of formal description techniques and is thus expensive.
Camille Fayollas +3 more
openaire +3 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source