Results 91 to 100 of about 1,976,702 (277)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Intractability Issues in Mixed-Criticality Scheduling [PDF]
, 2018 In seeking to develop mixed-criticality scheduling algorithms, one encounters challenges arising from two sources. First, mixed-criticality scheduling is an inherently an on-line problem in that scheduling decisions must be made without access to all the
Baruah, Sanjoy, Agrawal, Kunal
core +1 more source
SystemsComplex cyber-physical systems in the automotive and avionics domains increasingly consolidate safety-critical and non-critical functions onto shared multicore platforms.
Jaewoo Lee
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A toolset for the development of mixed-criticality partitioned systems [PDF]
, 2014 The development of mixed-criticality virtualized multi-core systems poses new challenges that are being subject of active research work. There is an additional complexity: it is now required to identify a set of partitions, and allocate applications to ...
Salazar Marsá, José Emilio +2 more
core +1 more source
Modeling Mixed-critical Systems in Real-time BIP
, 2013 International audienceThe proliferation of multi- and manycores creates an important design problem: the design and verification for mixed-criticality constraints in timing and safety, taking into account the resource sharing and hardware faults.
Bozga, Marius +3 more
core +1 more source
IEEE AccessMixed-Criticality (MC) systems have to guarantee the timely execution of high-criticality tasks even under adversarial processor conditions. Prior work addresses preemptive scheduling, leaving the NP hard, non-preemptive scheduling problem unexplored ...
Muhammad ElMahdy +2 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source