Results 201 to 210 of about 2,740 (260)

Unveiling Cortical Criticality Changes along the Prodromal to the Overt Continuum of Alpha-Synucleinopathy. [PDF]

J Neurosci
Roascio M, Wang SH, Myrov V, Siebenhühner F, Trò R, Mattioli P, Famà F, Morbelli SD, Pardini M, Orso B, Palva JM, Arnaldi D, Arnulfo G.   +12 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Design-integrated obsolescence diagnostics for sustainable manufacturing: a multi-dimensional evaluation framework. [PDF]

Sci Rep
Sierra-Fontalvo L, Ruiz-Pastor L, Gonzalez-Quiroga A, Mesa JA.   +3 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Cell jamming transitions can affect regulatory protein gradients and prime evolutionary divergence. [PDF]

J R Soc Interface
Badyaev AV, Lee CA, Gleason MJ, Semenov GA, Britton SE, Sánchez Moreno C, Duckworth RA.   +6 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Criticality and Magnetic Phases of Ising Shastry-Sutherland Candidate Holmium Tetraboride. [PDF]

Materials (Basel)
Khundzakishvili G, Belbase BP, Mahendran P, Zhang K, Xu H, Stoyanoff E, Checkelsky JG, Liu Y, Ye L, Banerjee A.   +9 more
europepmc   +1 more source

Structured interconnectivity optimizes neural geometry for balancing specificity and generalization in object recognition. [PDF]

Commun Biol
Zhang Y, Liu J, Liu J.
europepmc   +1 more source

Drug treatment alters performance in a neural microphysiological system of information processing. [PDF]

Commun Biol
Watmuff B, Habibollahi F, Desouza C, Khajehnejad M, Loeffler A, Baranes K, Poulin N, Kotter M, Kagan BJ.   +8 more
europepmc   +1 more source

The impact of large-class flipped classrooms incorporating design thinking on self-awareness, team collaboration, learning efficiency, and comprehensive literacy of clinical medicine undergraduates. [PDF]

BMC Med Educ
Zhang H, Wang X, Li X, Zhai J, Li X, Guo Y.   +5 more
europepmc   +1 more source