Results 21 to 30 of about 11,801 (261)

Structure and function of the bacterial heterodimeric ABC transporter CydDC: stimulation of ATPase activity by thiol and heme compounds. [PDF]

, 2014
In Escherichia coli, the biogenesis of both cytochrome bd-type quinol oxidases and periplasmic cytochromes requires the ATP-binding cassette-type cysteine/GSH transporter, CydDC.
Baldwin, SA, Booth, WI, Bullough, PA, Nyathi, Y, Poole, RK, Postis, V, Shepherd, M, Tzokov, SB, Xie, H, Yamashita, M   +9 more
core   +3 more sources

Reaction of O2 with a di-iron protein generates a mixed valent Fe2+/Fe3+ center and peroxide [PDF]

, 2019
The gene encoding the cyanobacterial ferritin SynFtn is up-regulated in response to copper stress. Here, we show that, while SynFtn does not interact directly with copper, it is highly unusual in several ways.
Bradley, Justin M., Hemmings, Andrew M., Hill, Natalie, Le Brun, Nick E., Moore, Geoffrey R., Palenik, Brian, Pullin, Jacob, Stuart, Rhona K., Svistunenko, Dimitri A., Wilson, Michael T.   +9 more
core   +2 more sources

Physiological and genetic description of dissimilatory perchlorate reduction by the novel marine bacterium Arcobacter sp. strain CAB. [PDF]

, 2013
A novel dissimilatory perchlorate-reducing bacterium (DPRB), Arcobacter sp. strain CAB, was isolated from a marina in Berkeley, CA. Phylogenetically, this halophile was most closely related to Arcobacter defluvii strain SW30-2 and Arcobacter ellisii ...
Bauer, Stefan, Carlström, Charlotte, COATES, John, Engelbrektson, Anna, Lee, Joyce, Melnyk, Ryan, Wang, Ouwei   +6 more
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Substrate Range and Genetic Analysis of Acinetobacter Vanillate Demethylase [PDF]

, 2000
An Acinetobacter sp. genetic screen was used to probe structure-function relationships in vanillate demethylase, a two-component monooxygenase. Mutants with null, leaky, and heat-sensitive phenotypes were isolated.
Morawski, Birgit, Ornston, L. Nicholas, Segura, Ana   +2 more
core  

A Flavin-dependent Monooxygenase from Mycobacterium tuberculosis Involved in Cholesterol Catabolism [PDF]

, 2010
Mycobacterium tuberculosis (Mtb) and Rhodococcus jostii RHA1 have similar cholesterol catabolic pathways. This pathway contributes to the pathogenicity of Mtb.
Ballou, Becker, Bhandari, Bradford, Brünger, Capyk, Chaiyen, Clark-Curtiss, Cornish-Bowden, DeLano, Dye, Eichhorn, Eltis, Faeder, Galán, Gisi, Hu, Hunter, Kabsch, Kadiyala, Kissinger, Lack, Mathieu, Mayo, Morris, Murshudov, Nakashima, Nesbitt, Otwinowski, Pandey, Payne, Rengarajan, Rosłoniec, Sambrook, Schneidman-Duhovny, Schüttelkopf, Seto, Stewart, Sucharitakul, Sucharitakul, Sucharitakul, Thibaut, Vaillancourt, Valton, Van der Geize, van der Geize, van der Geize, van der Geize, van der Geize, Xu, Xun, Xun, Yam, Yang, Zhang   +54 more
core   +2 more sources

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis [PDF]

, 2016
HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few
Drennan, Catherine L., Kang, Gyung Hoon, Liu, Hung-wen, Rabb, Jennifer, Zhong, Aoshu   +4 more
core   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source