Results 51 to 60 of about 1,925,062 (249)

Function-Coherent Gambles [PDF]

The desirable gambles framework provides a foundational approach to imprecise probability theory but relies heavily on linear utility assumptions. This paper introduces function-coherent gambles, a generalization that accommodates non-linear utility ...
Wheeler, Gregory
core   +3 more sources

The Great Gamble? A Mixed-Methods Study of Factors Influencing Medical Students in Specialty Choice

Journal of the Royal College of Physicians of Edinburgh, 2020
Background Career planning remains relatively unexplored as a domain of medical education. Our aim was to explore the career planning journey undertaken by medical students. Methods Mixed-methods data collection was employed. An online
Stefanie M, Croghan, Tom, Baker
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Acceptability of the content and functionality of a just-in-time adaptive intervention for gambling problems: a mixed-methods evaluation of gambling habit hacker

Addiction Science & Clinical Practice
Abstract Background Just-In-Time Adaptive Interventions (JITAIs) offer real-time support to help individuals adhere to gambling expenditure goals. This mixed-methods study evaluated the acceptability of a JITAI called Gambling Habit Hacker
S. N. Rodda, S. S. Merkouris, C. J. Greenwood, A. C. Thomas, D. I. Lubman, N. A. Dowling   +5 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

When to accept a sequence of gambles

, 2005
When is a sequence of gambles, which is initially rejected eventually accepted? The eventual acceptance is defined as a pair property between the utility function and the sequences of gambles.
Hammarlid, Ola,
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Gamble game: a pilot mixed-methods study on board games for adolescent gambling prevention in the school setting

Frontiers in Psychology
Adolescent gambling is an increasing public health concern, posing risks to emotional and social development. Despite legal prohibitions, the normalization of gambling through advertising and informal contexts promotes cognitive distortions and unrealistic expectancies among youth.
Paola Cardinali, Stefania Guasco, Fabio Boero, Martina Olcese   +3 more
openaire   +1 more source