Results 61 to 70 of about 1,925,062 (249)
, 2020 The premise of this thesis is that all business is embedded in society and needs to be responsible for the socio-cultural problems it creates. This thesis examines the social responsibilities operators should have to gamblers and wider society and seeks to understand if responsible gambling can empower gamblers to minimise harms.
openaire +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Teaching Games for Understanding and Athlete-Centred Coaching
, 2023 The pedagogies chosen by sport teachers and coaches are a powerful way to influence athletes’ development and sense of themselves. Athlete-centred coaching has emerged as a humanistic approach developed to engender empowerment and agency within the ...
Gambles, Ellen-Alyssa, Pill, Shane
core +2 more sources
Acceptance of mixed gambles is sensitive to the range of gains and losses experienced, and estimates of lambda (λ) are not a reliable measure of loss aversion: Reply to André and de Langhe (2020). [PDF]
J Exp Psychol Gen, 2021 Walasek L, Mullett TL, Stewart N.
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Detecting heterogeneous risk attitudes with mixed gambles [PDF]
, 2021 We propose a task for eliciting attitudes toward risk that is close to real-world risky decisions which typically involve gains and losses. The task consists of accepting or rejecting gambles that provide a gain with probability $$p$$ p and a loss with ...
Bruhin, Adrian +3 more
core
CADET: a collaborative agile data exploration tool for mixed reality
, 2023 The need to understand and communicate the nuances of complex situational information is an ever-present requirement in Command and Control (C2). It is often difficult for remote users of a system to clearly understand what a user is trying to relay ...
Mayer, W. +7 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source