Results 81 to 90 of about 208,068 (260)
Fastest Mixing Markov Chain on a Graph [PDF]
SIAM Review, 2004 The connected graph \(G=(V,E)\) with vertex set \(V=\{1,\dots,n\}\) and edge set \(E \subseteq V \times V\) is considered. It is assumed that \(G\) is a symmetric graph with self-loops, i.e. \((i,j) \in E\) iff \((j,i) \in E\) and \((i,i) \in E\) for all \(i\).
Stephen P. Boyd +2 more
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Do Graph Readers Prefer the Graph Type Most Suited to a Given Task? Insights from Eye Tracking
Journal of Eye Movement Research, 2016 Research on graph comprehension suggests that point differences are easier to read in bar graphs, while trends are easier to read in line graphs. But are graph readers able to detect and use the most suited graph type for a given task?
Benjamin Strobel +3 more
doaj +1 more source
A Geometric Property of the Laplacian matrix of a Connected Nonsingular Mixed Graph
Journal of Chemistry, 2020 In this paper, we give a geometric interpretation of the Laplacian matrix of a connected nonsingular mixed graph which generalizes the results of M. Fiedler (M. Fiedler, Geometry of the Laplacian, Linear Algebra Appl., 2005, 403: 409–413).
Zheng-Da Zhou, Shi-Cai Gong
doaj +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Graph Mixing Additive Networks
CoRRarXiv admin note: substantial text overlap with arXiv:2505 ...
Maya Bechler-Speicher +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source