Results 91 to 100 of about 712,475 (276)

Mixed Graph Colouring as Scheduling a Partially Ordered Set of Interruptible Multi-Processor Tasks with Integer Due Dates

Algorithms
We investigate relationships between scheduling problems with the bottleneck objective functions (minimising makespan or maximal lateness) and problems of optimal colourings of the mixed graphs. The investigated scheduling problems have integer durations
Evangelina I. Mihova, Yuri N. Sotskov
doaj   +1 more source

Graphical models in Macaulay2 [PDF]

, 2012
The Macaulay2 package GraphicalModels contains algorithms for the algebraic study of graphical models associated to undirected, directed and mixed graphs, and associated collections of conditional independence statements. Among the algorithms implemented
García-Puente, Luis David, Petrović, Sonja, Sullivant, Seth   +2 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, Volume 20, Issue 6, Page 1612-1625, June 2026.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

On Chromatic Number of Colored Mixed Graphs [PDF]

, 2017
An $(m,n)$-colored mixed graph $G$ is a graph with its arcs having one of the $m$ different colors and edges having one of the $n$ different colors. A homomorphism $f$ of an $(m,n)$-colored mixed graph $G$ to an $(m,n)$-colored mixed graph $H$ is a vertex mapping such that if $uv$ is an arc (edge) of color $c$ in $G$, then $f(u)f(v)$ is an arc (edge ...
Sandip Das 0001, Soumen Nandi, Sagnik Sen 0001   +2 more
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Nested Markov Properties for Acyclic Directed Mixed Graphs

, 2017
Directed acyclic graph (DAG) models may be characterized in at least four different ways: via a factorization, the d-separation criterion, the moralization criterion, and the local Markov property.
Evans, Robin J., Richardson, Thomas S., Robins, James M., Shpitser, Ilya   +3 more
core   +1 more source

On the Upward Planarity of Mixed Plane Graphs [PDF]

Journal of Graph Algorithms and Applications, 2013
Summary: A \textit{mixed plane graph} is a plane graph whose edge set is partitioned into a set of directed edges and a set of undirected edges. An \textit{orientation} of a mixed plane graph \(G\) is an assignment of directions to the undirected edges of \(G\) resulting in a directed plane graph \(\vec{G}\).
Fabrizio Frati, Michael Kaufmann 0001, János Pach, Csaba D. Tóth, David R. Wood   +4 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source