Results 101 to 110 of about 2,542,324 (299)

Mixed Graph Colouring as Scheduling a Partially Ordered Set of Interruptible Multi-Processor Tasks with Integer Due Dates

Algorithms
We investigate relationships between scheduling problems with the bottleneck objective functions (minimising makespan or maximal lateness) and problems of optimal colourings of the mixed graphs. The investigated scheduling problems have integer durations
Evangelina I. Mihova, Yuri N. Sotskov
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Forcing Domination Number of Hamiltonian Cubic Graphs [PDF]

, 2009
The authors presented a sequence of Hamiltonian cubic graphs whose domination numbers are sharp and in this paper we study forcing domination number for those ...
H. Abdollahzadeh Ahangar, H.Abdollahzadeh Ahangar, Abdollahzadeh Ahangar, H., Pushpalatha L.   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On the mixed domination problem in graphs

Theoretical Computer Science, 2013
A mixed dominating set of a simple graph G=(V,E) is a subset [email protected][email protected]?E such that every vertex or edge not in D is adjacent or incident to at least one vertex or edge in D. The mixed domination problem is to determine a minimum mixed dominating set of G.
James K. Lan, Gerard Jennhwa Chang
openaire   +1 more source

On Chromatic Number of Colored Mixed Graphs [PDF]

, 2017
An $(m,n)$-colored mixed graph $G$ is a graph with its arcs having one of the $m$ different colors and edges having one of the $n$ different colors. A homomorphism $f$ of an $(m,n)$-colored mixed graph $G$ to an $(m,n)$-colored mixed graph $H$ is a vertex mapping such that if $uv$ is an arc (edge) of color $c$ in $G$, then $f(u)f(v)$ is an arc (edge ...
Sandip Das 0001, Soumen Nandi, Sagnik Sen 0001   +2 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Asymmetric game perfect graphs and the circular coloring game of weighted graphs [PDF]

, 2011
Zacharopoulos P. Asymmetric game perfect graphs and the circular coloring game of weighted graphs.
Zacharopoulos, Panagiotis
core