Results 91 to 100 of about 591,196 (274)
Scientific Reports, 2018 The study aims to develop and assess and validate a brief diabetic foot ulceration risk checklist among diabetic patients through a longitudinal study.
Qiuhong Zhou +16 more
doaj +1 more source
Indicator function and complex coding for mixed fractional factorial designs
, 2007 In a general fractional factorial design, the $n$-levels of a factor are coded by the $n$-th roots of the unity. This device allows a full generalization to mixed-level designs of the theory of the polynomial indicator function which has already been ...
Pistone, Giovanni, Rogantin, Maria Piera
core +3 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Estimating the reliability of composite scores [PDF]
, 2009 In situations where multiple tests are administered (such as the GCSE subjects), scores from individual tests are frequently combined to produce a composite score.
He, Qingping
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Dependent Dirichlet Process Rating Model (DDP-RM) [PDF]
, 2013 Typical IRT rating-scale models assume that the rating category threshold parameters are the same over examinees. However, it can be argued that many rating data sets violate this assumption. To address this practical psychometric problem, we introduce a
Fujimoto, Ken Akira, Karabatsos, George
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Shortening the Alzheimer’s disease assessment scale cognitive subscale
European PsychiatryBackground A short yet reliable cognitive measure is needed that separates treatment and placebo for treatment trials for Alzheimer’s disease. Hence, we aimed to shorten the Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS-Cog) and test its ...
Stephen Z. Levine +8 more
doaj +1 more source