Results 71 to 80 of about 591,196 (274)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Development and validation of the health-related quality of life instrument for Chinese infertile couples: a mixed-methods study protocol

Health and Quality of Life Outcomes, 2022
Background Infertility and its treatment have negative impacts on a couple’s marital relationship, sexual life, psychological state and interpersonal relationships, causing personal distress. Health-related quality of life (HRQoL) has become an important
Zhao Shi, Zhuxin Mao, Hongwei Nie, Ling Geng, Gang Chen, Shunping Li   +5 more
doaj   +1 more source

Bayesian Games with Intentions

, 2016
We show that standard Bayesian games cannot represent the full spectrum of belief-dependent preferences. However, by introducing a fundamental distinction between intended and actual strategies, we remove this limitation.
Bjorndahl, Adam, Halpern, Joseph Y., Pass, Rafael   +2 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Harmonizing perspectives to understand attitudes: A mixed methods approach to crafting an assessment literacy attitude scale

International Journal of Assessment Tools in Education
Assessment literacy's vital role in faculty effectiveness within higher education lacks sufficient tools for measuring faculty attitudes on this matter. Employing a sequential mixed-methods approach, this study utilized the theory of planned behavior to ...
Stefanie Wind, Mehmet Can Demir, Beyza Aksu   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A mixed-binomial model for Likert-type personality measures

Frontiers in Psychology, 2014
Personality measurement is based on the idea that values on an unobservable latent variable determine the distribution of answers on a manifest response scale.
Jüri eAllik
doaj   +1 more source

The applicability of the decisional conflict scale in nursing home placement decision among Chinese family caregivers: A mixed methods approach

, 2017
This study aimed to 1) examine relationships between uncertainty, perceived information, personal values, social support, and filial obligation among Chinese family caregivers faced with nursing home placement of an older adult family member with ...
Chang, Yu-Ping, Schneider, Joanne Kraenzle, Sessanna, Loralee   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Illusory correlation, group size and memory [PDF]

, 2015
Two studies were conducted to test the predictions of a multi-component model of distinctiveness-based illusory correlation (IC) regarding the use of episodic and evaluative information in the production of the phenomenon.
Van Overwalle, Frank, Van Rooy, Dirk, Vanhoomissen, Tim   +2 more
core   +1 more source