Results 71 to 80 of about 14,419,663 (279)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Adaptation, further development and evaluation of the measurement properties of the person-centred community care inventory (PERCCI-S) for use in the Swedish municipal health care system

BMC Health Services Research
Background Successful implementation and sustainability of person-centred care (PCC) require continuous evaluations and valid measurements. While several instruments measure patients’ experience with PCC, to our knowledge, no validated instrument exists ...
Theresa Larsen, Richard Sawatzky, Helle Wijk, Ewa Wikström, Axel Wolf   +4 more
doaj   +1 more source

A mixed-binomial model for Likert-type personality measures

Frontiers in Psychology, 2014
Personality measurement is based on the idea that values on an unobservable latent variable determine the distribution of answers on a manifest response scale.
Jüri eAllik
doaj   +1 more source

The Estimation of Item Response Models with the lmer Function from the lme4 Package in R [PDF]

In this paper we elaborate on the potential of the lmer function from the lme4 package in R for item response (IRT) modeling. In line with the package, an IRT framework is described based on generalized linear mixed modeling. The aspects of the framework
Ivailo Partchev, Francis Tuerlinckx, Robert Zwitser, Abe Hofman, Marjan Bakker, Michel Nivard, Paul De Boeck   +6 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Marginal Maximum Likelihood Estimation of Item Response Models in R

Journal of Statistical Software, 2007
Item response theory (IRT) models are a class of statistical models used by researchers to describe the response behaviors of individuals to a set of categorically scored items.
Matthew S. Johnson
doaj  

Item response theory and the measurement of deprivation: Evidence from PSELL-3 [PDF]

Item Response Theory (IRT) has recently been proposed as a framework to measure deprivation. It allows deriving a latent measure of deprivation from a set of dichotomous observed items of deprivation and analyzing determinants of deprivation.
Fusco, Alessio, Raileanu Szeles, Monica
core  

Item response theory calibration results.

, 2019
Item response theory calibration results.
Janhavi Ajit Vaingankar (2164432), Mei Fen Chan (7109498), Julian Thumboo (427858), Elenore Judy Uy (6682673), Dianne Carrol Bautista (4839666), Geok Ling Lee (6469283), Terrance Siang Jin Chua (3170211), Nisha Kumar (6682676), Yin Bun Cheung (17908), Xiaohui Xin (4839663), Yunshan Xiao (5753005), Yu Heng Kwan (5066684), Mythily Subramaniam (446121)   +12 more
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

plink: An R Package for Linking Mixed-Format Tests Using IRT-Based Methods

Journal of Statistical Software, 2010
The R package plink has been developed to facilitate the linking of mixed-format tests for multiple groups under a common item design using unidimensional and multidimensional IRT-based methods.
Jonathan P. Weeks
doaj