Results 61 to 70 of about 13,961,135 (286)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Harmonizing perspectives to understand attitudes: A mixed methods approach to crafting an assessment literacy attitude scale

International Journal of Assessment Tools in Education
Assessment literacy's vital role in faculty effectiveness within higher education lacks sufficient tools for measuring faculty attitudes on this matter. Employing a sequential mixed-methods approach, this study utilized the theory of planned behavior to ...
Stefanie Wind, Mehmet Can Demir, Beyza Aksu   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Development and validation of the health-related quality of life instrument for Chinese infertile couples: a mixed-methods study protocol

Health and Quality of Life Outcomes, 2022
Background Infertility and its treatment have negative impacts on a couple’s marital relationship, sexual life, psychological state and interpersonal relationships, causing personal distress. Health-related quality of life (HRQoL) has become an important
Zhao Shi, Zhuxin Mao, Hongwei Nie, Ling Geng, Gang Chen, Shunping Li   +5 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Estimating the Multilevel Rasch Model: With the lme4 Package

Journal of Statistical Software, 2007
Traditional Rasch estimation of the item and student parameters via marginal maximum likelihood, joint maximum likelihood or conditional maximum likelihood, assume individuals in clustered settings are uncorrelated and items within a test that share a ...
Harold Doran, Douglas Bates, Paul Bliese, Maritza Dowling   +3 more
doaj  

Design and validation of the Disaster Health Literacy Questionnaire for diabetes patients in Iran: a mixed-methods study

BMJ Open
Objectives To develop and psychometrically evaluate a multidimensional Disaster Health Literacy Questionnaire (DHLQ) for diabetic patients in Iran, using advanced item response theory approaches.
Zahra Heidari, Golrokh Atighechian, Hasan Ashrafi-rizi, Somayeh Panahi, Maryam Heidarpour   +4 more
doaj   +1 more source

Clustering dichotomously scored items through functional k-means algorithm

, 2016
In the educational field, it is common to analyze the probability of a correct response to a test item as a continuous function of the item parameters and the subject ability. This relation is given by the item response function.
Di Battista, Tonio; Dipartimento di Metodi Quantitativi e Teoria Economica, Università "G. d'Annunzio" Chieti-Pescara, Fortuna, Francesca; DISFPEQ – University “G.d’Annunzio”, Pescara. Italy   +1 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A mixed-binomial model for Likert-type personality measures

Frontiers in Psychology, 2014
Personality measurement is based on the idea that values on an unobservable latent variable determine the distribution of answers on a manifest response scale.
Jüri eAllik
doaj   +1 more source