Results 61 to 70 of about 14,419,663 (279)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Harmonizing perspectives to understand attitudes: A mixed methods approach to crafting an assessment literacy attitude scale

International Journal of Assessment Tools in Education
Assessment literacy's vital role in faculty effectiveness within higher education lacks sufficient tools for measuring faculty attitudes on this matter. Employing a sequential mixed-methods approach, this study utilized the theory of planned behavior to ...
Stefanie Wind, Mehmet Can Demir, Beyza Aksu   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Estimating the Multilevel Rasch Model: With the lme4 Package

Journal of Statistical Software, 2007
Traditional Rasch estimation of the item and student parameters via marginal maximum likelihood, joint maximum likelihood or conditional maximum likelihood, assume individuals in clustered settings are uncorrelated and items within a test that share a ...
Harold Doran, Douglas Bates, Paul Bliese, Maritza Dowling   +3 more
doaj  

Design and validation of the Disaster Health Literacy Questionnaire for diabetes patients in Iran: a mixed-methods study

BMJ Open
Objectives To develop and psychometrically evaluate a multidimensional Disaster Health Literacy Questionnaire (DHLQ) for diabetic patients in Iran, using advanced item response theory approaches.
Zahra Heidari, Golrokh Atighechian, Hasan Ashrafi-rizi, Somayeh Panahi, Maryam Heidarpour   +4 more
doaj   +1 more source

Development and validation of the health-related quality of life instrument for Chinese infertile couples: a mixed-methods study protocol

Health and Quality of Life Outcomes, 2022
Background Infertility and its treatment have negative impacts on a couple’s marital relationship, sexual life, psychological state and interpersonal relationships, causing personal distress. Health-related quality of life (HRQoL) has become an important
Zhao Shi, Zhuxin Mao, Hongwei Nie, Ling Geng, Gang Chen, Shunping Li   +5 more
doaj   +1 more source

Using the area between two item response functions to index differential item functioning : a generalized approach [PDF]

, 1994
The area between two item response functions was used to construct two indicators of differential item functioning. The first indicator was designed from the integral of the difference of the two response functions across six standard deviations of ...
Penny, James A., NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

An Item Response Theory Approach to the Maintenance of Standards in Public Examinations in England [PDF]

, 2011
Every year outcomes from public examinations in the UK rise: politicians congratulate pupils on their hard earned achievement; the media questions whether this achievement is real; those responsible for administrating the examinations defend their ...
WHEADON, CHRISTOPHER,BRIAN, Wheadon, Christopher Brian   +1 more
core