Results 81 to 90 of about 6,168,058 (280)
Mixed finite element methods for linear elasticity with weakly imposed symmetry
, 2007 In this paper, we construct new finite element methods for the approximation of the equations of linear elasticity in three space dimensions that produce direct approximations to both stresses and displacements.
Arnold, Douglas N. +2 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Chow-Lin Methods in Spatial Mixed Models [PDF]
Missing data in dynamic panel models occur quite often since detailed recording of the dependent variable is often not possible at all observation points in time and space.
Carlos Llano +2 more
core
Numerical Experiments for Darcy Flow on a Surface Using Mixed Exterior Calculus Methods [PDF]
, 2011 There are very few results on mixed finite element methods on surfaces. A theory for the study of such methods was given recently by Holst and Stern, using a variational crimes framework in the context of finite element exterior calculus. However, we are
Hirani, Anil N., Kalyanaraman, Kaushik
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fast projections onto mixed-norm balls with applications
, 2012 Joint sparsity offers powerful structural cues for feature selection, especially for variables that are expected to demonstrate a "grouped" behavior. Such behavior is commonly modeled via group-lasso, multitask lasso, and related methods where feature ...
Sra, Suvrit
core +1 more source
Stepping beyond the paradigm wars: pluralist methods for research in learning technology
Research in Learning Technology, 2011 This paper outlines a problem we have found in our own practice when we have been developing new researchers at post-graduate level. When students begin research training and practice, they are often confused between different levels of thinking when ...
Chris Jones, Gregor Kennedy
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Mixed finite elements for numerical weather prediction
, 2012 We show how two-dimensional mixed finite element methods that satisfy the conditions of finite element exterior calculus can be used for the horizontal discretisation of dynamical cores for numerical weather prediction on pseudo-uniform grids.
Arakawa +29 more
core +1 more source