Results 91 to 100 of about 2,900,458 (300)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
NCRM podcast: The 'Thing-ness' problem of mixed methods research
, 2014 Is mixed methods research a turbulent environment and is innovation being stifled by an overly tightly bound concept of what it is? Sharlene Hesse-Biber, professor in the Sociology Department of Boston College thinks so.
Hesse-Biber, Sharlene
core
, 2023 Mixed-methods study framework showing how quantitative and qualitative methods address respective research questions.
Mahsa Adib (14700908) +2 more
core +1 more source
Studies in Digital Heritage, 2023 Accompanying excavation activities in the area of the Roman luxury villa of Capo di Sorrento, 3D models of the landscape and relevant features have been created using mostly Structure-from-Motion (SfM) since 2015. With this method, it was possible to create a digital surface model of the excavation site combining terrestrial, aerial, and underwater ...
Bernhard Fritsch +5 more
openaire +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Che genere di partecipazione? Indagine mix methods sui giovani napoletani di oggi
, 2018 Il progressivo allontanamento dei giovani dalla politica è testimoniato dalla loro difficoltà di partecipare socialmente e politicamente secondo canali standardizzati.
salvatore monaco, cristiano felaco
core
JISR Management and Social Sciences & Economics, 2017 The selection of an appropriate research method is extremely critical for a value added research. The purpose of this study is to critically review the academic literature of a mixed-methods research and to examine the philosophical and methodological ...
Salman Bashir +2 more
doaj +1 more source
Mixed Methods for Mixed Models
, 2014 This work bridges the frequentist and Bayesian approaches to mixed models by borrowing the best features from both camps: point estimation procedures are combined with priors to obtain accurate, fast inference while posterior simulation techniques are developed that approximate the likelihood with great precision for the purposes of assessing ...
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source