Results 61 to 70 of about 15,892,169 (298)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Changing the world with mixed methods
, 2018 From climate change to water security - there are some problems facing the world that often seem unsolvable. So how can researchers stay positive about the role they have in tackling these huge challenges and which research methods should they consider ...
Mertens, Donna
core +1 more source
Stifling silos: The need for a more holistic approach to mixed migration in a warming world [PDF]
, 2021 A climate-changed world is one of mixed migration taking place across a spectrum of time, space, and agency, with both positive and negative outcomes.
Zickgraf, Caroline
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
College students' justification for digital piracy: a mixed methods study
, 2012 Click on the DOI link to access the article (may not be free).A mixed methods project was devoted to understanding college students' justification for digital piracy.
Yu, Sz De
core +1 more source
MedEdPORTAL, 2008 Introduction Mixed methods research, collecting and analyzing both qualitative and quantitative data in a single study, is an effective approach for expanding and triangulating research findings, particularly in complex, real-world situations and ...
Karen Schifferdecker
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
, 2020 In this globalized era, mixed methods research (MMR) is widely utilized in various social and cultural research fields. However, integrating the qualitative and quantitative data rather than combining findings from both approaches remains a challenge for
Liu, Honggang, Li, Zongqiang
core +1 more source
BMJ Open, 2020 Objectives Although frequent emergency department (ED) use is a global issue, little research has been conducted in a country like Japan where universal health insurance is available. The study aims to (1) document the proportion of ED visits that are by
Makoto Kaneko +5 more
doaj +1 more source