Results 61 to 70 of about 394,923 (245)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Elasticity tetrads, mixed axial-gravitational anomalies, and (3+1)-d quantum Hall effect

Physical Review Research, 2019
For two-dimensional topological insulators, the integer and intrinsic (without external magnetic field) quantum Hall effect is described by the gauge anomalous (2+1)-dimensional [(2+1)-d] Chern-Simons (CS) response for the background gauge potential of ...
J. Nissinen, G. E. Volovik
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Computing dominant metric dimensions of certain connected networks

Heliyon
In the studies of the connected networks, metric dimension being a distance-based parameter got much more attention of the researches due to its wide range of applications in different areas of chemistry and computer science. At present its various types
Imtiaz Ali, Muhammad Javaid, Yilun Shang
doaj   +1 more source

Induced measures in the space of mixed quantum states

, 2001
We analyze several product measures in the space of mixed quantum states. In particular we study measures induced by the operation of partial tracing. The natural, rotationally invariant measure on the set of all pure states of a N x K composite system ...
Adelman M, Baker T H, Bengtsson I, Bouchaud J P, Burda Z, Bures D J C, Byrd M S, Fisher R A, Frieden B R, Haake F, Hans-Jürgen Sommers, Horn R, Hurwitz A, Jones K R W, Jones K R W, Karol Zyczkowski, Kendon V M, Lakshminarayan A, Lloyd S, Mahalonobis P C, Mehta M L, Pozniak M, Slater P B, Slater P B, Uhlmann A, Wootters W K, Zanardi P, Zyczkowski K, Zyczkowski K   +28 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

On Sasaki-Einstein manifolds in dimension five

, 2009
We prove the existence of Sasaki-Einstein metrics on certain simply connected 5-manifolds where until now existence was unknown. All of these manifolds have non-trivial torsion classes.
A. El Kacimi-Alaoui, A.G. Kouchnirenko, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, C.P. Boyer, Charles P. Boyer, D. Barden, J. Kollár, J. Kollár, J. Kollár, J.-P. Demailly, J.M. Johnson, J.P. Gauntlett, Michael Nakamaye, P. Orlik, P. Orlik, P. Orlik, S. Smale, S.S.-T. Yau   +26 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Non-conventional cosmology from a brane-universe

, 1999
We consider ``brane-universes'', where matter is confined to four-dimensional hypersurfaces (three-branes) whereas one extra compact dimension is felt by gravity only.
Antoniadis, Arkani-Hamed, Bailin, Cédric Deffayet, David Langlois, Dienes, Duff, Dvali, Hořava, Hořava, Ipser, Lyth, Pierre Binétruy, Vilenkin   +13 more
core   +1 more source