Results 71 to 80 of about 394,923 (245)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Metric considerations concerning the mixed Littlewood Conjecture [PDF]
, 2009 The main goal of this note is to develop a metrical theory of Diophantine approximation within the framework of the de Mathan-Teulie Conjecture, also known as the `Mixed Littlewood Conjecture'. Let p be a prime.
Bugeaud, Yann +2 more
core +1 more source
Geometry of Gaussian quantum states
, 2015 We study the Hilbert-Schmidt measure on the manifold of mixed Gaussian states in multi mode continuous variable quantum systems. An analytical expression for the Hilbert-Schmidt volume element is derived. Its corresponding probability measure can be used
Link, Valentin, Strunz, Walter T.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
On the classification of consistent boundary conditions for $ \mathit{f}(\mathit{R})$-Gravity
, 2018 Using a completely covariant approach, we discuss the role of boundary conditions (BCs) and the corresponding Gibbons--Hawking--York (GHY) terms in $ \mathit{f}(\mathit{R}) $-gravity in arbitrary dimensions.
Khodabakhshi, H. +2 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
, 2019 In this paper, we consider a symmetric pure jump Markov process $X$ on a general metric measure space that satisfies volume doubling conditions. We study estimates of the transition density $p(t,x,y)$ of $X$ and their stabilities when the jumping kernel ...
Bae, Joohak +3 more
core
Holographic Subregion Complexity for Singular Surfaces
, 2017 Recently holographic prescriptions are proposed to compute quantum complexity of a given state in the boundary theory. A specific proposal known as `holographic subregion complexity' is supposed to calculate the the complexity of a reduced density matrix
Bakhshaei, Elaheh +2 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source