Results 91 to 100 of about 1,992,399 (301)

Characterizing mixed mode oscillations shaped by noise and bifurcation structure

open access: yes, 2010
Many neuronal systems and models display a certain class of mixed mode oscillations (MMOs) consisting of periods of small amplitude oscillations interspersed with spikes.
Juan Luis Cabrera   +6 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Mixed-Mode: Past, Present, and Future

open access: yesSurvey Research Methods, 2018
Mixed-mode surveys have been around since the late 1980s. In the past thirty years, major changes in technology and society influenced and changed data collection and survey methodology. However, in those years, mixed-mode strategies remained part of the
Edith D. DeLeeuw
doaj   +1 more source

Criterion for mixed mode fracture in composite bonded joints [PDF]

open access: yes
A study was undertaken to characterize the debond growth mechanism of adhesively bonded composite joints under mode I, mixed mode I-II, and mode II static loadings. The bonded system consisted of graphite-epoxy composite adherends bonded with a toughened
Kochhar, N. K., Mall, S.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Measurements of mixed-mode crack surface displacements and comparison with theory [PDF]

open access: yes
A theoretical and an experimental technique is used to determine crack surface displacements under mixed-mode conditions. Crack surface displacements proved to be quite useful in mode 1 fracture analysis in that they are directly related to strain energy
Altiero, N. J., Jr., Sharpe, W. N., Jr.
core   +1 more source

Mixed Modes of Innovation [PDF]

open access: yesOECD Science, Technology and Industry Working Papers, 2012
This study uses exploratory data analysis techniques to develop typologies of innovation modes or strategies for groups of firms. Analysing micro-level survey data from 18 countries we identify five innovation modes. The coherence and relevance of the innovation modes is tested by using them as explanatory factors in equations explaining economic ...
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Slow Manifold Structure and the Emergence of Mixed-Mode Oscillations

open access: yes, 1997
A detailed study of the slow manifold of a model exhibiting mixed-mode oscillations is presented. A scenario for the emergence of mixed-mode states which does not involve phase locking on a 2-torus is constructed.
Goryachev, Andrei   +2 more
core   +1 more source

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