Results 101 to 110 of about 46,059 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Robust H-infinity sliding mode control for nonlinear stochastic systems with multiple data packet losses

open access: yes, 2012
This is the post-print version of this Article. The official published version can be accessed from the link below - Copyright @ 2012 John Wiley & SonsIn this paper, an ∞ sliding mode control (SMC) problem is studied for a class of discrete-time ...
Wang, Z, Ma, L, Bo, Y, Guo, Z
core   +1 more source

Impact of mixed modes on measurement errors and estimates of change in panel data

open access: yesSurvey Research Methods, 2015
Mixed mode designs are receiving increased interest as a possible solution for saving costs in panel surveys, although the lasting effects on data quality are unknown.
Alexandru Cernat
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Mixed-mode partition theories for one-dimensional fracture [PDF]

open access: yes, 2012
Many practical cases of fracture can be considered as one-dimensional, that is, propagating in one dimension and characterised by opening (mode I) and shearing (mode II) action only with no tearing (mode III) action.
Christopher M. Harvey (7119290)
core  

Synchronization of coupled neutral-type neural networks with jumping-mode-dependent discrete and unbounded distributed delays

open access: yes, 2013
This is the post-print version of the Article. The official published version can be accessed from the links below - Copyright @ 2013 IEEE.In this paper, the synchronization problem is studied for an array of N identical delayed neutral-type neural ...
Liu, Y   +11 more
core   +1 more source

Crack path modelling in railway wheel under rolling contact fatigue

open access: yesApplied and Computational Mechanics, 2015
A computational model of crack path for two-dimensional primary crack situated in a railway wheel rim is designed. The railway wheel rim is placed on the wheel disc of railway wheel with interference fit.
Kotoul M.
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Crack tip fields in elastic-plastic and mixed mode I+II+III conditions, finite elements simulations and modeling

open access: yesFracture and Structural Integrity, 2015
This paper is devoted to the analysis of the load path effect on I+II+III mixed mode fatigue crack propagation in a 316L stainless steel. Experiments were conducted in mode I+II and in mode I+II+III.
F. Fremy   +3 more
doaj  

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