Results 91 to 100 of about 4,734,824 (293)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Economic Vulnerability, Climate Change, and its Influence on School Enrolment: A Study of Dambatta Rural Community

Jurnal Ekonomi Pendidikan dan Kewirausahaan
Objective: The present study focused on exploring the influence of parents’ economic vulnerability in the agricultural sector on students’ enrollment in the Dambatta Local Government Area of Kano State, a rural community in Nigeria.
Abduljalal Salisu, Aniek Hindrayani, Feri Setyowibowo, Adamu Zakiyu Ubale   +3 more
doaj   +1 more source

A randomised trial and economic evaluation of the effect of response mode on response rate, response bias, and item non-response in a survey of doctors

BMC Medical Research Methodology, 2011
Background Surveys of doctors are an important data collection method in health services research. Ways to improve response rates, minimise survey response bias and item non-response, within a given budget, have not previously been addressed in the same ...
Witt Julia, Kalb Guyonne, Humphreys John S, Joyce Catherine M, Jeon Sung-Hee, Scott Anthony, Leahy Anne   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

An Approach to Predict Fatigue Delamination Propagation in Curved Composite Laminates Under Non-Constant Mixed-Mode Conditions: Experiments and Simulation Correlation

Engineering Proceedings
Composite laminates experience static and fatigue delamination, presenting significant challenges for failure prediction. This is critical in curved composites, where delamination behavior is complex to predict.
Carlos Mallor, Mario Sanchez, Andrea Calvo, Susana Calvo, Hubert R.-Wasik, Federico Martin de la Escalera   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation of Mixed-mode Integral Invariant for Polymer Material Trough The Couple Experimental-Numerical Process

EPJ Web of Conferences, 2010
Usually the element of real structures is subject of the mixed mode loadings. This fact can be explained by the elements geometry and the loading orientations.
Absi J., Dubois F., Pop O., Meite M.
doaj   +1 more source

Mixed-Mode: Past, Present, and Future

Survey Research Methods, 2018
Mixed-mode surveys have been around since the late 1980s. In the past thirty years, major changes in technology and society influenced and changed data collection and survey methodology. However, in those years, mixed-mode strategies remained part of the
Edith D. DeLeeuw
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source