Results 111 to 120 of about 1,992,399 (301)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Crack path modelling in railway wheel under rolling contact fatigue

Applied and Computational Mechanics, 2015
A computational model of crack path for two-dimensional primary crack situated in a railway wheel rim is designed. The railway wheel rim is placed on the wheel disc of railway wheel with interference fit.
Kotoul M.
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

One-Loop Amplitudes in Euclidean Quantum Gravity

, 1995
This paper studies the linearized gravitational field in the presence of boundaries. For this purpose, $\zeta$-function regularization is used to perform the mode-by-mode evaluation of BRST-invariant Faddeev-Popov amplitudes in the case of flat Euclidean
A.O. Barvinsky, A.O. Barvinsky, A.O. Barvinsky, A.Yu. Kamenshchik, B.S. DeWitt, C.W. Misner, D. McMullan, D.V. Vassilevich, D.V. Vassilevich, G. Esposito, G. Esposito, G. Esposito, G. Esposito, G. Esposito, H.C. Luckock, I.G. Moss, I.G. Moss, J. Louko, J.B. Hartle, K. Schleich, M. Henneaux, M. Henneaux, R.P. Feynman, S.W. Hawking, S.W. Hawking, S.W. Hawking, T.P. Branson   +26 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Atom-molecule coexistence and collective dynamics near a Feshbach resonance of cold fermions

, 2004
Degenerate Fermi gas interacting with molecules near Feshbach resonance is unstable with respect to formation of a mixed state in which atoms and molecules coexist as a coherent superposition.
A. V. Andreev, I. S. Gradshteyn, K. Hepp, L.  S. Levitov, M. O. Scully, R.  A. Barankov   +5 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Giant infrared intensity of the Peierls mode at the neutral-ionic phase transition

, 2002
We present exact diagonalization results on a modified Peierls-Hubbard model for the neutral-ionic phase transition. The ground state potential energy surface and the infrared intensity of the Peierls mode point to a strong, non-linear electron-phonon ...
A. Girlando, A. Girlando, A. J. Heeger, A. Lanzara, A. Painelli, A. Painelli, A. Y. Liu, Anna Painelli, C. Cojan, D. Baeriswyl, G. P. Borghi, J. B. Torrance, J. B. Torrance, K.-P. Bohnen, L. Farina, Luca Del Freo, M. J. Rice, M. Le Cointe, M. Masino, N. Nagaosa, N. Nagaosa, R. Bozio, R. J. McQueeney, R. Resta, R. Resta, S. Horiuchi, S. Horiuchi, T. Egami, T. Yildirim, W. H. Press, Y. Anusooya-Pati, Y. Okimoto, Z. G. Soos, Z. G. Soos, Z. G. Soos   +34 more
core   +1 more source