Results 71 to 80 of about 3,875,044 (290)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A Note on the Identifiability of Generalized Linear Mixed Models [PDF]

, 2014
I present here a simple proof that, under general regularity conditions, the standard parametrization of generalized linear mixed model is identifiable.
Labouriau, Rodrigo
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Mixed axion/neutralino cold dark matter in supersymmetric models

, 2011
We consider supersymmetric (SUSY) models wherein the strong CP problem is solved by the Peccei-Quinn (PQ) mechanism with a concommitant axion/axino supermultiplet.
, A. Brandenburg, A.P. Zhitnitskii, Andre Lessa, F.E. Paige, F.E. Paige, for a model-independent approach, For a recent review, G.F. Giudice, H. Baer, H. Baer, H. Baer, H. Baer, H. Baer, Howard Baer, L. Covi, L. Covi, P. Svrček, S. Asztalos, Shibi Rajagopalan, Warintorn Sreethawong, WMAP collaboration   +21 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Adaptabilidade e estabilidade da produção de borracha e seleção em progênies de seringueira Adaptability and stability of rubber production and selection in rubber tree progenies

Pesquisa Agropecuária Brasileira, 2009
Os objetivos deste trabalho foram determinar a interação genótipo x ambiente e a estabilidade e adaptabilidade da produção de borracha em progênies de seringueira (Hevea brasiliensis (Willd. ex A. Juss.) Müll. Arg.), bem como estimar o ganho genético com
Cecília Khusala Verardi, Marcos Deon Vilela de Resende, Reginaldo Brito da Costa, Paulo de Souza Gonçalves   +3 more
doaj   +1 more source

Variational approximation for mixtures of linear mixed models

, 2012
Mixtures of linear mixed models (MLMMs) are useful for clustering grouped data and can be estimated by likelihood maximization through the EM algorithm.
Armagan A., Attias H., Booth J.G., Corduneanu A., David J. Nott, Dempster A.P., Meng X.L., Papaspiliopoulos O., Sahu S.K., Scharl T., Siew Li Tan, Verbeek J.J., Wang B., Waterhouse S., Winn J., Wu B., Yeung K.Y., ———   +17 more
core   +2 more sources

Mixed Model-Based Hazard Estimation [PDF]

Journal of Computational & Graphical Statistics, 2002
We propose a new method for estimation of the hazard function from a set of censored failure time data, with a view to extending the general approach to more complicated models. The approach is based on a mixed model representation of penalized spline hazard estimators.
Cai, T., Hyndman, R.J., Wand, M.P.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mixed Inflaton and Spectator Field Models after Planck

, 2013
We investigate the possibility that the primordial perturbation has two sources: the inflaton and a spectator field, which is not dynamically important during inflation but which after inflation can contribute to the curvature perturbation.
Enqvist, Kari, Takahashi, Tomo
core   +1 more source