Results 81 to 90 of about 1,513,668 (313)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Covariate random effects on the CD4 count variation during HIV disease progression in women

HIV/AIDS: Research and Palliative Care, 2019
Partson Tinarwo, Temesgen Zewotir, Delia NorthSchool of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban, South AfricaPurpose: To investigate the variation in CD4 count between HIV positive patients due to clinical ...
Tinarwo P, Zewotir T, North D
doaj  

EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis

Genetics Selection Evolution, 2000
This paper presents procedures for implementing the EM algorithm to compute REML estimates of variance covariance components in Gaussian mixed models for longitudinal data analysis.
Robert-Granié Christèle, Jaffrézic Florence, Foulley Jean-Louis   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Goodness-of-fit tests in mixed models. [PDF]

Mixed models, with both random and fixed effects, are most often estimated on the assumption that the random effects are normally distributed. In this paper we propose several formal tests of the hypothesis that the random effects and/or errors are ...
Claeskens, Gerda, Hart, Jeffrey D.
core  

Selection indexes in the simultaneous increment of yield components in topcross hybrids of green maize [PDF]

Pesquisa Agropecuária Brasileira
: The objective of this work was to define the most suitable selective strategy for the simultaneous increment of yield components of green maize, by comparing three selection indexes weighted by economic weights and by the REML/BLUP method, in the ...
Willame dos Santos Candido, Caique Machado e Silva, Maraiza Lima Costa, Bruna Elaine de Almeida Silva, Beatriz Lima de Miranda, Jefferson Fernando Naves Pinto, Edésio Fialho dos Reis   +6 more
doaj   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Quasi-Monte Carlo EM algorithm for MLEs in generalized linear mixed models

, 1998
Inferences for generalized linear mixed models are greatly hampered by the intractable integrated likelihood. In this paper numerical integration based on Quasi-Monte Carlo method is used to approximate the integral of the EM algorithm and then to fit ...
Robin Thompson, Thompson, R., Pan, J-X, Jian-Xin Pan   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The PX-EM algorithm for fast stable fitting of Henderson's mixed model

Genetics Selection Evolution, 2000
This paper presents procedures for implementing the PX-EM algorithm of Liu, Rubin and Wu to compute REML estimates of variance covariance components in Henderson's linear mixed models.
Van Dyk David A, Foulley Jean-Louis
doaj   +1 more source