Results 81 to 90 of about 3,858,904 (290)

Modelling tribimaximal neutrino mixing [PDF]

Physical Review D, 2009
We model tri-bimaximal lepton mixing from first principles in a way that avoids the problem of the vacuum alignment characteristic of such models. This is achieved by using a softly broken A4 symmetry realized with an isotriplet fermion, also triplet under A4. No scalar A4-triplet is introduced.
Hirsch, Martin, Morisi, S., Furtado Valle, José Wagner   +2 more
openaire   +4 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

EM-REML estimation of covariance parameters in Gaussian mixed models for longitudinal data analysis

Genetics Selection Evolution, 2000
This paper presents procedures for implementing the EM algorithm to compute REML estimates of variance covariance components in Gaussian mixed models for longitudinal data analysis.
Robert-Granié Christèle, Jaffrézic Florence, Foulley Jean-Louis   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Unraveling the genetic potential of Indian rice germplasm for reproductive stage drought tolerance

Frontiers in Plant Science
Climate change poses a serious threat to future food security on a global scale. Drought is the most challenging abiotic stress, limiting rice production in rainfed rice ecosystems. Therefore, an experiment was designed under three distinct environments,
Santhiya Subramanian, Pushpam Ramamoorthy, Subramanian Alagesan, John Joel Amalraj, Raveendran Muthurajan, Senthil Alagarsamy, Muthuramu Sengalan, Suresh Ramalingam, Pravin Kumar Kathiresan, Parthiban Thathapalli Prakash   +9 more
doaj   +1 more source

Selection indexes in the simultaneous increment of yield components in topcross hybrids of green maize [PDF]

Pesquisa Agropecuária Brasileira
: The objective of this work was to define the most suitable selective strategy for the simultaneous increment of yield components of green maize, by comparing three selection indexes weighted by economic weights and by the REML/BLUP method, in the ...
Willame dos Santos Candido, Caique Machado e Silva, Maraiza Lima Costa, Bruna Elaine de Almeida Silva, Beatriz Lima de Miranda, Jefferson Fernando Naves Pinto, Edésio Fialho dos Reis   +6 more
doaj   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Combining Partially Overlapping Multi-Omics Data in Databases Using Relationship Matrices

Frontiers in Plant Science, 2020
Private and public breeding programs, as well as companies and universities, have developed different genomics technologies that have resulted in the generation of unprecedented amounts of sequence data, which bring new challenges in terms of data ...
Deniz Akdemir, Ron Knox, Julio Isidro y Sánchez, Julio Isidro y Sánchez   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The PX-EM algorithm for fast stable fitting of Henderson's mixed model

Genetics Selection Evolution, 2000
This paper presents procedures for implementing the PX-EM algorithm of Liu, Rubin and Wu to compute REML estimates of variance covariance components in Henderson's linear mixed models.
Van Dyk David A, Foulley Jean-Louis
doaj   +1 more source