Results 191 to 200 of about 11,753,613 (221)

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

TMEM59L promotes neuroendocrine differentiation and enzalutamide resistance in prostate cancer by regulating MUC1/β‐catenin/MYC axis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Enzalutamide‐mediated AR suppression induces TMEM59L during prostate cancer progression. TMEM59L interacts with MUC1 and promotes its nuclear enrichment. Nuclear MUC1 activates β‐catenin/TCF4‐dependent MYC signalling, driving neuroendocrine differentiation, stemness and EMT.
Xiuchen Guo, Yifan Liu, Jiacheng Huang, Zhiwei Chen, Haihong Liao, Yulin Xu, Xingang Cui, Yongjiang Yu   +7 more
wiley   +1 more source

Pyrroline‐5‐carboxylate reductase 1 interacts with Nudix hydrolase 5 to drive bladder cancer malignant progression via activation of the APOE/JAK2/STAT3 signalling axis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Pyrroline‐5‐carboxylate reductase 1, via Nudix hydrolase 5 (NUDT5)‑dependent nuclear ATP production, promotes SP1‑mediated Apolipoprotein E (APOE) transcription. APOE, in turn, activates the JAK2/STAT3 signalling pathway, thereby promoting proliferative and metastatic capacities of bladder cancer cells.
Haotian Chen, Shuya Ji, Pengfei Wu, Ji Liu, Wentao Zhang, Yadong Guo, Jingcheng Zhang, Zhijing Zhang, YanLing Liu, Yongqiang Liu, Chengqi Jin, Sichen Di, Yang Wu, Junfeng Zhang, Xiaojun Zhu, Shiyu Mao, Bing Shen, Xudong Yao   +17 more
wiley   +1 more source

Oral Copaiba Oil‐Resin Supplementation Reduces Plasma and Hepatic Oxidative Stress in Female and Male Hypothalamic‐Obese Animals

Food Science &Nutrition, Volume 14, Issue 9, September 2026.
Oral supplementation with copaiba‐oil resin (Co‐resin) restores hepatic and plasma oxidative systems in hypothalamic‐obese male and female rats, therefore, it showed a more positive impact on females. This study highlights the therapeutic potential of Co‐resin to reduce reactive oxygen species production and restore plasma and hepatic antioxidant ...
Sirlei P. Souza, Zoé M. N. de Carvalho, Beatriz M. Daudt, Marianela A. F. Urrutia, Caroline M. Aguiar, Ellen C. Z. Gomes, Mustafa M. M. Dahleh, Marina Prigol, Gustavo P. Guerra, Lucinéia F. C. Ribeiro, Sabrina Grassiolli   +10 more
wiley   +1 more source

Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT Langerhans cell histiocytosis (LCH) is a rare clonal myeloid neoplasm. Canadian data on clinical characteristics, molecular profile, and treatment outcomes is limited. This study aims to report the initial experience of a Canadian rare diseases program, reflecting “real‐world” diagnostic pathways, referral patterns, and treatment heterogeneity
Stephanie Quon, Yaswanta Gummadi, Ibrahim Elsharawi, Jessica Dobson, Mariam Goubran, Ryan J. Stubbins, Eli L. Diamond, Luke Y. C. Chen   +7 more
wiley   +1 more source

MUC1 as a Survival Effector of Radiotherapy‐Induced Epithelial Hybrid States in Basal‐Like Breast Cancer

International Journal of Cancer, Volume 159, Issue 5, Page 1296-1310, 1 September 2026.
Basal‐like breast cancer (BLBC) is aggressive and often exhibits inherent or acquired resistance to radiotherapy (RT), a primary treatment option. RT resistance is underpinned by molecular alterations, many of which are poorly understood. Here, RT‐induced transcriptomic changes were analyzed using bulk and spatial sequencing in a BLBC mouse model and ...
Garyfallia Pantelaiou‐Prokaki, Husam Bamahmoud, Nadine S. Georges, Shaishavi Jansari, Annika Jung, Daniela Grimm, Evangelos Prokakis, Fabian Alexander Gayer, Maryam Deldar, Christian Dullin, Julia Gallwas, Florian Wegwitz, Frauke Alves   +12 more
wiley   +1 more source

Transcriptome‐Based Classification of Resected Pancreatic Ductal Adenocarcinoma Enhances Prognostic Modelling Accuracy of Overall Survival Following Adjuvant Treatment

International Journal of Cancer, Volume 159, Issue 5, Page 1322-1336, 1 September 2026.
Outcomes after resection of pancreatic ductal adenocarcinoma remain highly variable, and existing prognostic models lack sufficient accuracy. Here, the authors aimed to improve survival prediction by integrating transcriptome‐based subtyping into a validated clinical model and applying it to a multicenter real‐world cohort of fresh‐frozen resection ...
Marjolein F. Lansbergen, Vincent R. Lanting, Paul Manoukian, Marc G. Besselink, Geert Kazemier, Ignace H. J. T. de Hingh, Mike S. L. Liem, Casper H. J. van Eijck, Erwin van der Harst, Vincent E. de Meijer, Ronald M. van Dam, Martijn W. J. Stommel, Jan Koster, Michael W. T. Tanck, Arantza Fariña Sarasqueta, Joanne Verheij, Frederike Dijk, Johanna W. Wilmink, Maarten F. Bijlsma, Hanneke W. M. van Laarhoven, for the Dutch Pancreatic Cancer Group   +20 more
wiley   +1 more source

Upper Urinary Tract Carcinoma With Primary Small Cell Neuroendocrine Cancer—Case Report and Review of Literature

IJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Upper Urinary Tract Small Cell Neuroendocrine Ca are extremely rare carcinomas with less than 40 reported cases in literature. Case 92 years old male with left flank pain and diagnosed to have an enhancing renal pelvic mass, which on histopathological examination was noted to have a predominant small cell carcinoma component ...
Siddhant Kumar, Sunil Pillai Bhaskara, A. V. B. Krishnakanth, Abhijit Shah, Siddalingeshwara Chandragouda Doddamani, Padmaraj hegde, Arun Chawla   +6 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, Volume 46, Issue 9, Page 3274-3287, September 2026.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, Volume 40, Issue 18, September 2026.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source