Results 71 to 80 of about 11,753,613 (221)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Pancreatic neuroendocrine neoplasms: Clinicopathological features and pathological staging.

, 2020
The nomenclature and classification of pancreatic neuroendocrine neoplasms has evolved in the last 15 years based on the advances in knowledge of the genomics, clinical behaviour and response to therapies.
Lam, Alfred King-Yin, Ishida, Hirotaka
core   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Neuroendocrine Neoplasms of the Gut

, 2020
Neuroendocrine neoplasms of the gut are a heterogeneous group of tumors showing different morphological, clinical, prognostic, and molecular features. Currently, these proliferations are classified as “neuroendocrine neoplasms” (NENs), which include two ...
Rindi, Guido, Silvia Uccella, Uccella, Silvia, Stefano La Rosa, Guido Rindi, La Rosa, Stefano   +5 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Distinct Adenocarcinoma and Neuroendocrine Carcinoma Components (Suspected Mixed Neuroendocrine‐Non‐Neuroendocrine Neoplasm) Identified by Targeted Biopsy Based on Differences in Endoscopic Findings in an Esophagogastric Junction Carcinoma: A Case Report

DEN Open
Mixed neuroendocrine‐non‐neuroendocrine neoplasm (MiNEN) is a rare, highly malignant tumor comprising both neuroendocrine neoplasm (NEN) and non‐neuroendocrine neoplasm (non‐NEN) components. MiNEN arising at the esophagogastric junction (EGJ) is uncommon,
Kakeru Miyashita, Manabu Takeuchi, Takahiro Taguchi, Seiichi Yoshikawa, Keisuke Morita, Masaru Kumagai, Kazuki Natsui, Yohei Koseki, Natsuki Ishikawa, Erina Kodama   +9 more
doaj   +1 more source

Neuroendocrine neoplasms of the small bowel and pancreas [PDF]

, 2019
The traditionally promulgated perspectives of neuroendocrine neoplasms as rare, indolent tumours are blunt and have been outdated for the last two decades.
Frilling, Andrea, Baum, Richard P., Oberg, Kjell, Kidd, Mark,, Kidd, Mark, Frilling, Andrea,, Clift, Ashley Kieran, Toumpanakis, Christos,, Baum, Richard P, Bodei, Lisa, Baum, Richard P.,, Clift, Ashley K, Modlin, Irvin, Öberg, Kjell,, Toumpanakis, Christos, Clift, Ashley Kieran,, Modlin, Irvin M.,, Bodei, Lisa,, Modlin, Irvin M.   +18 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?

Frontiers in Endocrinology
BackgroundGallbladder mixed neuroendocrine-non-neuroendocrine neoplasm generally consists of a gallbladder neuroendocrine tumor and a non-neuroendocrine component.
Ya-Fei Hu, Ya-Fei Hu, Jun-Ke Wang, Jun-Ke Wang, Wen-Jie Ma, Wen-Jie Ma, Hai-Jie Hu, Hai-Jie Hu, Han-Fei Gu, Han-Fei Gu, Fei Liu, Fei Liu, Tian-Run Lv, Tian-Run Lv, Si-Qi Yang, Si-Qi Yang, Yu-Shi Dai, Yu-Shi Dai, Rui-Qi Zou, Rui-Qi Zou, Yan-Wen Jin, Yan-Wen Jin, Fu-Yu Li, Fu-Yu Li   +23 more
doaj   +1 more source

Neuroendocrine neoplasm sections submitted for quantitative proteomics.

, 2023
H&E stained histologic sections of the 2 gallbladder neuroendocrine neoplasms (left panel, middle panel) and the hepatic neuroendocrine neoplasm (right panel). Scrolls of these sections were submitted for proteomic analysis.
Daniel Paulsen (5500241), Andrea N. Johnston (14504545), Bonnie Boudreaux (10895018), Emi Sasaki (11981004), Chin-Chi Liu (9210758), Joshua Sparago (14504539), Stephanie D. Byrum (3873991), Mayzie Miller (14504536), Tifini L. Batts (14504533), Rudy W. Bauer (14504542)   +9 more
core   +1 more source