Results 51 to 60 of about 1,286,114 (315)

Computational aspects of N-mixture models [PDF]

, 2015
The N-mixture model is widely used to estimate the abundance of a population in the presence of unknown detection probability from only a set of counts subject to spatial and temporal replication (Royle, 2004, Biometrics 60,105–115).
Morgan, Byron J. T., Morgan, Byron J T, Dennis, Emily B., Ridout, Martin S.   +3 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Models for the Response of a Mixture

Journal of the Royal Statistical Society Series B: Statistical Methodology, 1968
Summary Care needs to be exercised in the choice of model for a mixture system. The polynomial model, for example, cannot satisfactorily account for components which are inert or have additive effects and its coefficients lose their interpretative value when the variables are the proportions of components in the mixture.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A Hierarchical Bayesian Model for the Identification of PET Markers Associated to the Prediction of Surgical Outcome after Anterior Temporal Lobe Resection

Frontiers in Neuroscience, 2017
We develop an integrative Bayesian predictive modeling framework that identifies individual pathological brain states based on the selection of fluoro-deoxyglucose positron emission tomography (PET) imaging biomarkers and evaluates the association of ...
Sharon Chiang, Sharon Chiang, Michele Guindani, Hsiang J. Yeh, Sandra Dewar, Zulfi Haneef, John M. Stern, Marina Vannucci   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Determining Genetic Causal Variants Through Multivariate Regression Using Mixture Model Penalty

Frontiers in Genetics, 2018
With the availability of high-throughput sequencing data, identification of genetic causal variants accurately requires the efficient incorporation of function annotation data into the optimization routine.
V. S. Sundar, V. S. Sundar, Chun-Chieh Fan, Chun-Chieh Fan, Dominic Holland, Dominic Holland, Anders M. Dale, Anders M. Dale, Anders M. Dale, Anders M. Dale   +9 more
doaj   +1 more source

Phylogenetic mixture models for proteins [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
Standard protein substitution models use a single amino acid replacement rate matrix that summarizes the biological, chemical and physical properties of amino acids. However, site evolution is highly heterogeneous and depends on many factors: genetic code; solvent exposure; secondary and tertiary structure; protein function; etc.
Le Si, Quang, Lartillot, Nicolas, Gascuel, Olivier   +2 more
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

CorrDA: correlation-matrix driven discriminant analysis

Statistical Theory and Related Fields
This article introduces a novel approach to integrating correlation matrix information from training samples to construct a classification rule for testing samples.
Feifei Yan, Yingjie Zhang, Jing Ning, Hai Shu, Ziqi Chen   +4 more
doaj   +1 more source