Results 71 to 80 of about 1,286,114 (315)

Using weibull mixture distributions to model heterogeneous survival data [PDF]

, 2003
In this article we use Bayesian methods to fit a Weibull mixture model with an unknown number of components to possibly right censored survival data. This is done using the recently developed, birth-death MCMC algorithm.
Marín Díazaraque, Juan Miguel, Rodríguez Bernal, María Teresa, Marín, J. Miguel, Wiper, Michael Peter, Wiper, Michael P., Rodríguez Bernal, M. T.   +5 more
core  

Quantifying the impact of inter-site heterogeneity on the distribution of ChIP-seq data

Frontiers in Genetics, 2014
Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is a valuable tool for epigenetic studies. Analysis of the data arising from ChIP-seq experiments often requires implicit or explicit statistical modelling of the read counts.
Jonathan eCairns, Jonathan eCairns, Andy G Lynch, Simon eTavaré   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Directed Clustering of Multivariate Data Based on Linear or Quadratic Latent Variable Models

Algorithms
We consider situations in which the clustering of some multivariate data is desired, which establishes an ordering of the clusters with respect to an underlying latent variable.
Yingjuan Zhang, Jochen Einbeck
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

PolSAR Image Classification Based on Statistical Distribution and MRF

Remote Sensing, 2020
Classification is an important topic in synthetic aperture radar (SAR) image processing and interpretation. Because of speckle and imaging geometrical distortions, land cover mapping is always a challenging task especially in complex landscapes.
Junjun Yin, Xiyun Liu, Jian Yang, Chih-Yuan Chu, Yang-Lang Chang   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The standardization of linear and nonlinear effects in direct and indirect applications of structural equation mixture models

Frontiers in Psychology, 2015
The application of mixture models to flexibly estimate linear and nonlinear effects in the SEM framework has received increasing attention (e.g., Bauer, 2005; Jedidi, Jagpal, & DeSarbo, 1997b; Kelava & Brandt, 2014; B. O. Muthén & Asparouhov, 2009, 2014;
Holger eBrandt, Nora eUmbach, Augustin eKelava   +2 more
doaj   +1 more source

Unifying Epidemic Models With Mixtures

IEEE Transactions on Signal and Information Processing over Networks
The COVID-19 pandemic has emphasized the need for a robust understanding of epidemic models. Current models of epidemics are classified as either mechanistic or non-mechanistic: mechanistic models make explicit assumptions on the dynamics of disease, whereas non-mechanistic models make assumptions on the form of observed time series. Here, we introduce
Arnab Sarker, Ali Jadbabaie, Devavrat Shah   +2 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source