Results 71 to 80 of about 15,569,368 (309)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Quantifying the impact of inter-site heterogeneity on the distribution of ChIP-seq data
Frontiers in Genetics, 2014 Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) is a valuable tool for epigenetic studies. Analysis of the data arising from ChIP-seq experiments often requires implicit or explicit statistical modelling of the read counts.
Jonathan eCairns +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Mixture models for distance sampling detection functions [PDF]
, 2015 Funding: EPSRC DTGWe present a new class of models for the detection function in distance sampling surveys of wildlife populations, based on finite mixtures of simple parametric key functions such as the half-normal. The models share many of the features
David L. Miller (167484) +8 more
core +2 more sources
Directed Clustering of Multivariate Data Based on Linear or Quadratic Latent Variable Models
AlgorithmsWe consider situations in which the clustering of some multivariate data is desired, which establishes an ordering of the clusters with respect to an underlying latent variable.
Yingjuan Zhang, Jochen Einbeck
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Online Quantum Mixture Regression for Trajectory Learning by Demonstration [PDF]
, 2013 16/01/14 MEB. Pre-print version OK to add.In this work, we present the online Quantum Mixture Model (oQMM), which combines the merits of quantum mechanics and stochastic optimization. More specifically it allows for quantum effects on the mixture states,
Dimitrios Korkinof +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]
The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Magnus, Jan R., Boldea, Otilia
core
Frontiers in Psychology, 2015 The application of mixture models to flexibly estimate linear and nonlinear effects in the SEM framework has received increasing attention (e.g., Bauer, 2005; Jedidi, Jagpal, & DeSarbo, 1997b; Kelava & Brandt, 2014; B. O. Muthén & Asparouhov, 2009, 2014;
Holger eBrandt +2 more
doaj +1 more source