Results 91 to 100 of about 6,741 (226)
, 2023 ObjectiveSpinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is a rare neurodegenerative disease for which there is no specific treatment. Very few cases have been treated with single-target deep brain stimulation (DBS), and
Yan Chang (486484) +6 more
core +1 more source
Journal of Child Psychology and Psychiatry, EarlyView.Background There are no evaluated family‐based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole‐family interventions in low‐ and middle‐income countries, despite consistent evidence for the impact of family support on mental health and well‐being. This study aims to
Tania Bosqui +21 more
wiley +1 more source
, 2013 Spinocerebellar ataxia type 3 (SCA3) also known as Machado-Joseph Disease (MJD), is one of nine polyglutamine (polyQ) diseases caused by a CAG-trinucelotide repeat expansion within the coding sequence of the ATXN3 gene.
Jiping Yi +7 more
openalex +3 more sources
Hsp104 delays aggregation of truncated MJD, but enhances aggregation of full-length MJD.
, 2013 (A and B) With the rh1-GAL4 driver at indicated time points, cryosections and IHC demonstrate accumulations of MJDtrQ78 and MJDnQ78 (red) over time, using anti-HA and anti-myc antibodies, respectively.
James Shorter (42154) +2 more
core +1 more source
A Spectrum of Support: Parental Involvement in the Lives of Autistic College Students
Journal of Marriage and Family, EarlyView.ABSTRACT Objective This study investigated how parents of autistic college students are involved in preparing their students for college and in their college lives, how their involvement is affected by student, family, and institutional characteristics, and how they balance their involvement with support for autonomy.
Jane D. McLeod +2 more
wiley +1 more source
Distribution of the GGGGCC repeats size in SCA3/MJD patients and controls.
, 2015 There was no significant difference in the distribution of the GGGGCC repeats length between SCA3/MJD patients and controls.
Zhao Chen (92571) +13 more
core +1 more source
Reinforcement Learning for Jump‐Diffusions, With Financial Applications
Mathematical Finance, EarlyView.ABSTRACT We study continuous‐time reinforcement learning (RL) for stochastic control in which system dynamics are governed by jump‐diffusion processes. We formulate an entropy‐regularized exploratory control problem with stochastic policies to capture the exploration–exploitation balance essential for RL.
Xuefeng Gao, Lingfei Li, Xun Yu Zhou
wiley +1 more source
Hsp104 mitigates toxicity of Truncated MJD but enhances toxicity of Full-length MJD.
, 2013 (A) With the 1×gr-GAL4 driver at d7, Hsp104 alone had minimal disruption to external eye and internal retinal structure. Arrows indicate the width of the retina to highlight changes in tissue integrity.
James Shorter (42154) +2 more
core +1 more source
Neurobiology of Disease, 2010 Machado–Joseph disease (MJD) is a late-onset neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in the ataxin-3 protein. We generated two transgenic mouse lineages expressing the expanded human ataxin-3 under the control of the CMV ...
Anabela Silva-Fernandes +11 more
doaj +1 more source
miR-6780-5p-Enriched Exosomes Derived From Butylidenephthalide-Pre-Conditioned Human Olfactory Ensheathing Cells Via Autophagy Improve Motor Coordination and Balance in a SCA3/MJD Mouse Model [PDF]
, 2021 Yu-Shuan Chen +12 more
openalex +1 more source