Results 71 to 80 of about 6,741 (226)

A portion of the Josephin domain and the Ubiquitin-Interacting Motifs prevent Hsp104 from rescuing full-length MJD pathogenicity.

, 2013
(A) With the 1×gr-GAL4 driver at d7, external eye and internal retinal structure showed suppression of toxicity by Hsp104 for MJD variants with mutated UIMs (MJD-Q80-UIM* and MJD-Q80-C14A-UIM*).
James Shorter (42154), Mimi Cushman-Nick (454359), Nancy M. Bonini (227332)   +2 more
core   +1 more source

The blood-brain barrier is disrupted in Machado-Joseph disease/spinocerebellar ataxia type 3: evidence from transgenic mice and human post-mortem samples

Acta Neuropathologica Communications, 2020
Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in spinocerebellar ataxias (SCAs) such as Machado-Joseph disease/SCA type 3 (MJD/SCA3), a genetic disorder, triggered by ...
Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida   +8 more
doaj   +1 more source

Profiling Microglia in a Mouse Model of Machado–Joseph Disease

Biomedicines, 2022
Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs.
Ana Bela Campos, Sara Duarte-Silva, Bruno Fernandes, Sofia Pereira das Neves, Fernanda Marques, Andreia Teixeira-Castro, Andreia Neves-Carvalho, Daniela Monteiro-Fernandes, Camila Cabral Portugal, Renato Socodato, Teresa Summavielle, António Francisco Ambrósio, João Bettencourt Relvas, Patrícia Maciel   +13 more
doaj   +1 more source

Chemically Modular, Nonfluorinated Polymer Adsorbents for Capturing Per‐ and Polyfluoroalkyl Substances (PFAS)

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Nonfluorinated polymer networks for PFAS adsorption are synthesized using active ester click chemistry. Incorporating Lewis base ligands along with hydrophilic and hydrophobic co‐monomers leads to high PFOA binding efficiency. Ligand basicity and pH are found to play an important role in PFOA sorption.
Lakshay K. Dhamania, Joshua D. Moon
wiley   +1 more source

Parkinsonian phenotype in Machado-Joseph disease (MJD/SCA3) : a two-case report

, 2021
Background: Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder of late onset, which is caused by a CAG repeat expansion in the coding region of the ATXN3 gene.
Lima, Manuela, Heutink, Peter, Pereira dos Santos, Cristina Maria, Raposo, Mafalda, Cymbron, Teresa, Coutinho, Paula, Kay, Teresa, Bettencourt, Conceição, Rizzu, Patrizia, Vasconcelos, João   +9 more
core  

Human Capital Robotic Integration and Value Creation for Organizations

Journal of Organizational Behavior, EarlyView.
ABSTRACT Due to rapid advancements in artificial intelligence and machine learning, the research conversation has drifted from viewing robots as replacements for humans (i.e., the substitute view) to a view that considers the possible benefits of human–robot collaboration in the workplace (i.e., the complementary view).
Chou‐Yu Tsai, Jason D. Marshall, Rory Eckardt, Shelley D. Dionne, Malte F. Jung, YoYo Tsung‐Yu Hou, Biying Yang   +6 more
wiley   +1 more source

Therapeutic mechanisms of modified Jiawei Juanbi decoction in early knee osteoarthritis: A multimodal analysis

Heliyon
Modified Jiawei Juanbi decoction (MJD) is used for the treatment of early-stage knee osteoarthritis (KOA). Here, modified Jiawei Juanbi decoction (MJD) was employed for the treatment of early-stage knee osteoarthritis (KOA) and its mechanisms were ...
Kun Gao, Zhenyu Huang, Weiji Yu, Yihong Wu, Weidong Liu, Shufen Sun, Yong Zhang, Dayu Chen   +7 more
doaj   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Sleep disorders among Aboriginal Australians with Machado-Joseph Disease: Quantitative results from a multiple methods study to assess the experience of people living with the disease and their caregivers

Neurobiology of Sleep and Circadian Rhythms, 2022
Background: Machado-Joseph Disease (MJD), or Spinocerebellar Ataxia Type 3 (SCA3), is a genetic disorder that causes progressive muscle weakness, loss of motor control, ataxia and permanent physical disability.
Desireé LaGrappe, Libby Massey, Anuk Kruavit, Timothy Howarth, Gayangwa Lalara, Bronwyn Daniels, Julie Gungunbuy Wunungmurra, Kimberley Flavell, Ruth Barker, Howard Flavell, Subash S. Heraganahally   +10 more
doaj   +1 more source

Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register‐Based Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess temporal trends in outcomes of pregnancies with maternal or paternal type 1 diabetes compared to the general population. Design Register‐based study. Setting Denmark. Population 1 551 893 pregnancies from 1997 to 2021, hereof 5478 with maternal and 8072 with paternal type 1 diabetes.
Tina Wullum Gundersen, Sine Knorr, Lene Ringholm, Dorte Moeller Jensen, Peter Damm, Karoline Kragelund Nielsen, Helena Backman, Jeannet Lauenborg, Elisabeth Reinhardt Mathiesen, Anne Helby Petersen, Niels Skipper, Allan Kofoed‐Enevoldsen, Tine Dalsgaard Clausen   +12 more
wiley   +1 more source