Results 51 to 60 of about 4,884 (187)

Therapeutic mechanisms of modified Jiawei Juanbi decoction in early knee osteoarthritis: A multimodal analysis

Heliyon
Modified Jiawei Juanbi decoction (MJD) is used for the treatment of early-stage knee osteoarthritis (KOA). Here, modified Jiawei Juanbi decoction (MJD) was employed for the treatment of early-stage knee osteoarthritis (KOA) and its mechanisms were ...
Kun Gao, Zhenyu Huang, Weiji Yu, Yihong Wu, Weidong Liu, Shufen Sun, Yong Zhang, Dayu Chen   +7 more
doaj   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

Resource Availability Modulates Effects of Fluorine Free Firefighting Foams

Environmental Toxicology, EarlyView.
ABSTRACT Fluorine‐free foam (F3) alternatives that lack per‐ and polyfluoroalkyl substances (PFAS) are rapidly being adopted for firefighting operations and will be entering ecosystems. Despite this, little is known about their impact on freshwater communities.
Jack D. Morehouse, Lucas A. Cacula, Jason T. Hoverman   +2 more
wiley   +1 more source

Sleep disorders among Aboriginal Australians with Machado-Joseph Disease: Quantitative results from a multiple methods study to assess the experience of people living with the disease and their caregivers

Neurobiology of Sleep and Circadian Rhythms, 2022
Background: Machado-Joseph Disease (MJD), or Spinocerebellar Ataxia Type 3 (SCA3), is a genetic disorder that causes progressive muscle weakness, loss of motor control, ataxia and permanent physical disability.
Desireé LaGrappe, Libby Massey, Anuk Kruavit, Timothy Howarth, Gayangwa Lalara, Bronwyn Daniels, Julie Gungunbuy Wunungmurra, Kimberley Flavell, Ruth Barker, Howard Flavell, Subash S. Heraganahally   +10 more
doaj   +1 more source

Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register‐Based Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess temporal trends in outcomes of pregnancies with maternal or paternal type 1 diabetes compared to the general population. Design Register‐based study. Setting Denmark. Population 1 551 893 pregnancies from 1997 to 2021, hereof 5478 with maternal and 8072 with paternal type 1 diabetes.
Tina Wullum Gundersen, Sine Knorr, Lene Ringholm, Dorte Moeller Jensen, Peter Damm, Karoline Kragelund Nielsen, Helena Backman, Jeannet Lauenborg, Elisabeth Reinhardt Mathiesen, Anne Helby Petersen, Niels Skipper, Allan Kofoed‐Enevoldsen, Tine Dalsgaard Clausen   +12 more
wiley   +1 more source

The gene for Machado–Joseph disease maps to the same 3-cM interval as the spinal cerebellar ataxia 3 gene on chromosome 14q

Neurobiology of Disease, 1994
Machado–Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder in families of Portuguese–Azorean ancestry. The gene responsible for MJD has been assigned to a 29-cM interval on chromosome 14q.
G. Stevanin, P.S. Sousa, G. Cancel, A. Dürr, O. Dubourg, G.A. Nicholson, J. Weissenbach, E. Jardim, Y. Agid, E. Cassa, A. Brice   +10 more
doaj   +1 more source

Diagnostic validation of the 00325 Inadequate Self‐Compassion

International Journal of Nursing Knowledge, EarlyView.
Abstract Background Self‐compassion is an essential component of self‐care. Recognizing it as a nursing diagnosis can promote interventions to address Inadequate Self‐Compassion. Aim This study aims to clinically validate the new NANDA‐I diagnosis (00325) Inadequate Self‐Compassion.
Aarón Muñoz‐Devesa, Daniel Guillén‐Martínez, Adriana Caterina de Souza‐Oliveira, Daniel Muñoz‐Jimenez, Paloma Echevarría‐Pérez, Isabel Morales‐Moreno   +5 more
wiley   +1 more source

Compound heterozygous intermediate MJD alleles cause cerebellar ataxia with sensory neuropathy [PDF]

Neurology Genetics, 2017
Spinocerebellar degeneration (SCD) is a group of disorders characterized by progressive ataxia caused by dysfunction and atrophy of the cerebellum or its projections. Approximately one-third of SCD cases are familial SCD, the majority of which are attributed to CAG triplet repeat expansions including spinocerebellar ataxia (SCA)1, SCA2, Machado-Joseph ...
Takahashi, Yuji, Kanai, Masahiro, Taminato, Tomoya, Watanabe, Shoko, Matsumoto, Chihiro, Araki, Toshiyuki, Okamoto, Tomoko, Ogawa, Masafumi, Murata, Miho   +8 more
openaire   +2 more sources

Interventions for binge eating disorder in adults with type 2 diabetes: A systematic review

Diabetic Medicine, EarlyView.
Abstract Aims Binge eating disorder frequently co‐occurs with type 2 diabetes, creating a dual burden that may complicate both psychological well‐being and glycaemic management. Evidence on the effectiveness of health interventions in this population is limited.
Pernille Fiil Nybo, Nikolaj Vang Nielsen, Julie Drotner Mouritsen, Michael Einar Røder, Jakob Linnet   +4 more
wiley   +1 more source

A multistep mutation mechanism drives the evolution of the CAG repeat at MJD/SCA3 locus [PDF]

European Journal of Human Genetics, 2006
Despite the intense debate around the repeat instability reported on the large group of neurological disorders caused by trinucleotide repeat expansions, little is known about the mutation process underlying alleles in the normal range that, ultimately, expand to pathological size.
Wong, VCN, Calafell, F, Sequeiros, J, Amorim, A, Martins, S   +4 more
openaire   +4 more sources