Results 41 to 50 of about 4,884 (187)
Frontiers in Genetics, 2019 Long non-coding RNAs (lncRNAs) play an important role in growth, development, and reproduction and undoubtedly contribute to the pathogenesis and progression of diseases.
Tianjiao Li +18 more
doaj +1 more source
Revisiting Variable Stars Toward the Globular Cluster NGC 6496 With ATLAS and Gaia Photometry
Astronomische Nachrichten, EarlyView.ABSTRACT We revisit 13 variable stars in the field of the metal‐rich globular cluster NGC 6496, discovered by Abbas et al. (2015; Astronomical Journal 149:40) (hereafter referred to as “MA15”) via time‐series data, spanning 2 years. We improve upon the MA15 characterization of the variables using ATLAS time‐series photometry data, spanning 8 years, in ...
Madison E. Martin +2 more
wiley +1 more source
Gene-Related Cerebellar Neurodegeneration in SCA3/MJD: A Case-Controlled Imaging-Genetic Study
Frontiers in Neurology, 2019 Background: Spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD) is one of the nine polyglutamine (polyQ) diseases and is caused by a CAG repeat expansion within the coding sequence of the ATXN3 gene.
Huirong Peng +19 more
doaj +1 more source
Acta Neuropathologica Communications, 2020 Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in spinocerebellar ataxias (SCAs) such as Machado-Joseph disease/SCA type 3 (MJD/SCA3), a genetic disorder, triggered by ...
Diana Duarte Lobo +8 more
doaj +1 more source
Profiling Microglia in a Mouse Model of Machado–Joseph Disease
Biomedicines, 2022 Microglia have been increasingly implicated in neurodegenerative diseases (NDs), and specific disease associated microglia (DAM) profiles have been defined for several of these NDs.
Ana Bela Campos +13 more
doaj +1 more source
ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.Nonfluorinated polymer networks for PFAS adsorption are synthesized using active ester click chemistry. Incorporating Lewis base ligands along with hydrophilic and hydrophobic co‐monomers leads to high PFOA binding efficiency. Ligand basicity and pH are found to play an important role in PFOA sorption.
Lakshay K. Dhamania, Joshua D. Moon
wiley +1 more source
CAG tract of MJD-1 may be prone to frameshifts causing polyalanine accumulation [PDF]
Human Molecular Genetics, 2000 Machado-Joseph disease (MJD) is one of several disorders caused by the expansion of a coding CAG repeat (exp-CAG). The presence of intranuclear inclusions (INIs) in patients and cellular models of exp-CAG-associated diseases has lead to a nuclear toxicity model.
C, Gaspar +6 more
openaire +2 more sources
Frontiers in Genetics, 2022 Hepatocellular carcinoma (HCC) is one of the most common gastrointestinal malignancies. It is not easy to be diagnosed in the early stage and is prone to relapse, with a very poor prognosis. And immune cell infiltration and tumor microenvironment play important roles in predicting therapeutic response and prognosis of HCC.
Lei Zhou +11 more
openaire +3 more sources
Epilepsia, EarlyView.Abstract Objective Elevated body temperature may increase seizure risk, yet the relationship between thermoregulation and seizures, as well as the underlying mechanisms, remains poorly understood. We investigated whether thermoregulatory control is altered in experimental temporal lobe epilepsy (TLE), as such impairment could reduce the ability of ...
Rossella Di Sapia +19 more
wiley +1 more source
Human Capital Robotic Integration and Value Creation for Organizations
Journal of Organizational Behavior, EarlyView.ABSTRACT Due to rapid advancements in artificial intelligence and machine learning, the research conversation has drifted from viewing robots as replacements for humans (i.e., the substitute view) to a view that considers the possible benefits of human–robot collaboration in the workplace (i.e., the complementary view).
Chou‐Yu Tsai +6 more
wiley +1 more source