Results 31 to 40 of about 4,884 (187)
Research on Mitochondrial DNA Mutations in Patients with SCA3/MJD [PDF]
, 2017 Abstract Spinocerebellar ataxia type 3 (SCA3) is a degenerative neurological disorders caused by trinucleotide repeat expansion within the ataxin-3 gene. It is characterized by multi-system involvement and diverse clinical phenotypes, which cannot be fully explained the length of the CAG repeats.
Liu, Zhen +8 more
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Comparison of GBM, GFBM and MJD Models in Malaysian Rubber Prices Forecasting
Malaysian Journal of Fundamental and Applied Sciences, 2023 This research studies three mathematical models, namely geometric Brownian motion (GBM), geometric fractional Brownian motion (GFBM) model which was developed by adding the Hurst parameter to GBM to characterize the long-memory phenomenon, and Merton jump-diffusion (MJD) model which captures shocks via GBM.
Siti Nur Iqmal Ibrahim +1 more
openaire +1 more source
Peripheral Oxidative Stress Biomarkers in Spinocerebellar Ataxia Type 3/Machado–Joseph Disease
Frontiers in Neurology, 2017 ObjectivesSpinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a polyglutamine disorder with no current disease-modifying treatment. Conformational changes in mutant ataxin-3 trigger different pathogenic cascades, including reactive oxygen ...
Adriano M. de Assis +39 more
doaj +1 more source
EpigeneticsMachado-Joseph disease (MJD) is an autosomal dominant spinocerebellar ataxia (SCA) caused by a polyglutamine expansion in the ataxin-3 protein, which initiates a cascade of pathogenic events, including transcriptional dysregulation.
Luís Teves +6 more
doaj +1 more source
Neurobiology of Disease, 2021 Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder that affects movement coordination leading to a premature death. Despite several efforts, no disease-modifying treatment is yet available for
Joana Pereira-Sousa +9 more
doaj +1 more source
Anthroponymy evolution of Javanese diaspora names in Malaysia (social onomastics study)
Frontiers in Sociology, 2023 The personal name of the Malaysian Javanese Diaspora (MJD) grows and develops along with the history of dynamic life, thought, social, and cultural developments.
Sahid Teguh Widodo +3 more
doaj +1 more source
Advanced Science, EarlyView.. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li +15 more
wiley +1 more source
Genetics and Molecular Biology, 2003 Spinocerebellar ataxia type 1 (SCA1) and Machado-Joseph disease (MJD/SCA3) are autosomal dominant neurodegenerative diseases caused by expansions of a CAG trinucleotide repeat in the SCA1 and MJD genes.
Cláudia Emília Vieira Wiezel +2 more
doaj +1 more source
Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors
Advanced Science, EarlyView.Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu +4 more
wiley +1 more source
A cost analysis of Machado-Joseph’s disease (MJD)
PLOS ONEA rare disease is that with a low prevalence in the population. However, it is estimated that there are between 6,000 and 8,000 different types of rare diseases in the world and, generally, they are incurable and deadly. Machado-Joseph’s disease (MJD) is one of these cases; of genetic origin, autosomal dominant, with a high chance of transmission ...
Cristiane da Silva +2 more
openaire +3 more sources