Results 61 to 70 of about 4,884 (187)
Neuropeptide Y (NPY) intranasal delivery alleviates Machado–Joseph disease
Scientific Reports, 2021 Machado–Joseph disease (MJD) is the most common dominantly-inherited ataxia worldwide with no effective treatment to prevent, stop or alleviate its progression. Neuropeptide Y (NPY) is a neuroprotective agent widely expressed in the mammalian brain.
Joana Duarte-Neves +2 more
doaj +1 more source
Scientific Reports, 2022 The establishment of robust human brain organoids to model cerebellar diseases is essential to study new therapeutic strategies for cerebellum-associated disorders.
João Brás +9 more
doaj +1 more source
Journal of Child Psychology and Psychiatry, EarlyView.Background There are no evaluated family‐based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole‐family interventions in low‐ and middle‐income countries, despite consistent evidence for the impact of family support on mental health and well‐being. This study aims to
Tania Bosqui +21 more
wiley +1 more source
A Spectrum of Support: Parental Involvement in the Lives of Autistic College Students
Journal of Marriage and Family, EarlyView.ABSTRACT Objective This study investigated how parents of autistic college students are involved in preparing their students for college and in their college lives, how their involvement is affected by student, family, and institutional characteristics, and how they balance their involvement with support for autonomy.
Jane D. McLeod +2 more
wiley +1 more source
Reinforcement Learning for Jump‐Diffusions, With Financial Applications
Mathematical Finance, EarlyView.ABSTRACT We study continuous‐time reinforcement learning (RL) for stochastic control in which system dynamics are governed by jump‐diffusion processes. We formulate an entropy‐regularized exploratory control problem with stochastic policies to capture the exploration–exploitation balance essential for RL.
Xuefeng Gao, Lingfei Li, Xun Yu Zhou
wiley +1 more source
Management of Surgical Margins in the Excision of Oral Leukoplakia: A Scoping Review
Oral Diseases, EarlyView.ABSTRACT Objective To map the literature on management of surgical margins for oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Methods Searches were performed in five electronic databases and gray literature. Studies involving patients undergoing any type of surgical excision of OL or PVL were included.
Mateus José Dutra +8 more
wiley +1 more source
Aboriginal families living with MJD in remote Australia: questions of access and equity
International Journal for Equity in HealthAbstractManaging genetic disease using medically assisted reproductive technology is increasingly promoted as a feasible option, given revolutionary advances in genomics. Far less attention has been directed to the issue of whether there is equitable access to this option.
Massey, Libby +4 more
openaire +5 more sources
De‐Coupled Water and Nitrogen Translocation From Subsoil to Canopy of Temperate Forest Trees
Plant, Cell &Environment, EarlyView.ABSTRACT Water and nitrogen (N) transport from soil to canopy play a central role in tree functioning, yet direct evidence for their timing and coupling in mature forests remains scarce. We report results from a paired dual‐isotope (2H, 15N) tracer experiment in a temperate forest, comparing water and nitrate uptake patterns across tree species ...
Klara Mrak +7 more
wiley +1 more source
Neurobiology of Disease, 2010 Machado–Joseph disease (MJD) is a late-onset neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in the ataxin-3 protein. We generated two transgenic mouse lineages expressing the expanded human ataxin-3 under the control of the CMV ...
Anabela Silva-Fernandes +11 more
doaj +1 more source
Annals of Neurology, Volume 100, Issue 3, Page 613-627, September 2026.Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera +16 more
wiley +1 more source