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Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.
Cancer research, 1999An3 1 KAL I MutL homologue 1 (MLH1) is a member of the family of proteins required for DNA mismatch repair. Germ-line mutations in MLH1 lead to the cancer susceptibility syndrome hereditary nonpolyposis colorectal cancer (HNPCC). We generated mice carrying a null mutation in the Mlh1 gene.
W, Edelmann +9 more
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Association between the MLH1 gene and longevity
Human Genetics, 2006Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity.
Dong Jo, Kim +6 more
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Cancer research, 1999
The DNA mismatch repair gene hMLH1 is reported to function in mutation avoidance, cell cycle checkpoint control, the cytotoxicity of various DNA-damaging agents, and transcription-coupled nucleotide excision repair. Formal proof of the involvement of hMLH1 in these processes requires single gene complementation.
A B, Buermeyer +3 more
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The DNA mismatch repair gene hMLH1 is reported to function in mutation avoidance, cell cycle checkpoint control, the cytotoxicity of various DNA-damaging agents, and transcription-coupled nucleotide excision repair. Formal proof of the involvement of hMLH1 in these processes requires single gene complementation.
A B, Buermeyer +3 more
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Identification of constitutional MLH1 methylation in MLH1-deficient colorectal cancer
Human PathologyJun Wang +8 more
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