Results 91 to 100 of about 16,106 (168)
Haematologica, 2013 The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of clinico-biological variables in different age cohorts, we analyzed 5202 patients with acute ...
Sabina Chiaretti +24 more
doaj +1 more source
Clinical Case Reports, Volume 13, Issue 1, January 2025.Key Clinical Message Extreme hyperleukocytosis (Leukocyte count >200 × 109/L) in an adolescent young adult (AYA) patient with B‐ALL could result in mild symptoms of leukostasis. Hyperleukocytosis requires prompt initiation of therapy with adequate hydration, cytoreduction and prevention of tumor lysis.
Gulten Tikit +4 more
wiley +1 more source
bioRxivMLL-rearranged (MLLr) leukemia is an aggressive form of acute leukemia driven by chromosomal translocations fusing MLL with one of more than 100 partner genes, most commonly AF4. We previously showed that expression of the human MLL-AF4 fusion protein in
Aina Louise C. Haukeland +6 more
semanticscholar +1 more source
How CBX proteins regulate normal and leukemic blood cells
FEBS Letters, Volume 598, Issue 22, Page 2788-2806, November 2024.CBX proteins are epigenetic reader proteins that can recognize histone modifications and thereby dictate cell fate. In this review, we describe how CBX proteins dictate cell fate in normal hematopoiesis and leukemia. In addition, we discuss which CBX proteins can promote leukemic cell growth and whether pharmacological inhibition of CBX proteins can ...
Anne P. de Groot, Gerald de Haan
wiley +1 more source
A new KAT on the block rewrites the epigenetic script in menin inhibitor‐resistant leukemia
HemaSphere, Volume 9, Issue 11, November 2025.
Yizhou Huang, Charles E. de Bock
wiley +1 more source
Haematologica, 2010 Background The t(9;22) and t(4;11) chromosomal translocations, which generate the BCR-ABL and MLL-AF4 fusion genes, define high-risk subtypes of acute lymphoblastic leukemia in adults.
Thomas Burmeister +7 more
doaj +1 more source
Stem Cell Reports, 2016 Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages.
Alvaro Muñoz-López +26 more
doaj +1 more source
CD34 Positivity and Aberrant Marker Expression by Blasts of B-ALL Patients [PDF]
Research Journal of Applied BiotechnologyBackground: Acute leukemia, specifically Acute lymphoblastic leukemia (B-ALL), poses significant diagnostic and therapeutic challenges due to its complex biology and varied antigen expression.Objective: the study aims to analyze CD34 expression ...
Ahmed AlFarouk +3 more
doaj +1 more source