Results 81 to 90 of about 16,106 (168)
Advances in Hematology, 2011 Translocation t(4;11)(q21;q23) leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients.
F. Marchesi, K. Girardi, G. Avvisati
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Cells, 2019 The MLL (mixed-lineage leukemia) gene, located on chromosome 11q23, is involved in chromosomal translocations in a subtype of acute leukemia, which represents approximately 10% of acute lymphoblastic leukemia and 2.8% of acute myeloid leukemia cases ...
Oliver Britten +3 more
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Processing of DNA Topoisomerase II–DNA–Protein Crosslinks Associated With Anticancer Drugs
Genes to Cells, Volume 31, Issue 1, January 2026.Topoisomerase II (TOP2) relieving DNA torsional stress is trapped by TOP2 poisons, such as etoposide, inducing DNA double‐strand breaks (DSBs) bearing TOP2–DNA–protein crosslinks (TOP2–DPCs), which must be removed before DSB repair. This review summarizes the TOP2–DPC resolution processes mediated by multiple pathways, including proteolysis and ...
Ryo Sakasai, Kuniyoshi Iwabuchi
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Cells, 2019 Leukemias bearing mixed lineage leukemia (MLL) rearrangement (MLL-R) resulting in expression of oncogenic MLL fusion proteins (MLL-FPs) represent an especially aggressive disease subtype with the worst overall prognoses and chemotherapeutic response. MLL-
Aditya Barve +7 more
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Advanced Healthcare Materials, Volume 14, Issue 27, October 20, 2025.This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah +9 more
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The RNA Binding Protein IGF2BP3 Is Required for MLL-AF4 Mediated Leukemogenesis
Blood, 2020 Chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene are observed in acute lymphoblastic leukemias (ALL), acute myeloid leukemias (AML), and in rare mixed-lineage leukemia. Despite recent progress in therapeutic approaches, patients with MLL-rearranged (MLLr) leukemias still have very poor outcomes and a high risk of relapse.
Tiffany Tran +13 more
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Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia
BioEssays, Volume 47, Issue 6, June 2025.Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
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DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation
Nature Communications, 2019 Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL ...
Laura Godfrey +13 more
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Incidence of common preleukemic gene fusions in umbilical cord blood in Slovak population.
PLoS ONE, 2014 The first event in origination of many childhood leukemias is likely the presence of preleukemic clone (transformed hematopoietic stem/progenitor cells with preleukemic gene fusions (PGF)) in newborn. Thus, the screening of umbilical cord blood (UCB) for
Milan Škorvaga +7 more
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Minimal Residual Disease Detection: Implications for Clinical Diagnosis and Cancer Patient Treatment
MedComm, Volume 6, Issue 6, June 2025.Currently, a variety of methods such as flow cytometry, polymerase chain reaction, next‐generation sequencing, and other emerging methods are used for the detection of minimal residual disease, each of which has its own unique strengths and limitations and, more importantly, promising clinical applications.
Meiling Song +10 more
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