Results 101 to 110 of about 16,106 (168)

The function of PRC2 in MLL-AF4 acute lymphoid leukaemia

, 2015
The MLL-AF4 fusion protein is the most prevalent MLL rearrangement in acute lymphoid leukaemia. It is associated with a very poor prognosis with median overall survival of 10 months in children. Epigenetic therapy is a promising new approach for the treatment haematological malignancies.
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Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia.

PLoS ONE, 2014
Here we present a novel method "Genomic inverse PCR for exploration of ligated breakpoints" (GIPFEL) that allows the sensitive detection of recurrent chromosomal translocations.
Elisa Fueller, Daniel Schaefer, Ute Fischer, Pina F I Krell, Martin Stanulla, Arndt Borkhardt, Robert K Slany   +6 more
doaj   +1 more source

Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants

Haematologica, 2013
Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen, Eddy H.J. van Roon, Jill A.P. Spijkers-Hagelstein, Pauline Schneider, Paola de Lorenzo, Maria Grazia Valsecchi, Rob Pieters, Ronald W. Stam   +7 more
doaj   +1 more source

An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia: a multi-center study of 381 patients

Haematologica, 2008
In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with ...
Hareth Nahi, Hans Hägglund, Thomas Ahlgren, Per Bernell, Mats Hardling, Karin Karlsson, Vladimir Lj Lazarevic, Mats Linderholm, Bengt Smedmyr, Maria Åström, Helene Hallböök   +10 more
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MLL-AF4 fusion transcripts in Acute Lymphocytic Leukemia patientsin Children hospital of Tabriz

Iranian South Medical Journal, 2014
Background: MLL-AF4 positive Leukemias comprise about 50-70% of acute lymphoid leukemias in children and about 5% of adolescents and adults Despite recent advances in the treatment of hematologic malignancies of children with ALL in particular, but it ...
Amir Monfaredan, Seyyed Mahmood Tabatabaei, Nahideh Karimian Fathi, Azim Rezamand   +3 more
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Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia

Scientific Reports
Proteasome inhibitors (PIs) bortezomib, carfilzomib and ixazomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have clinical activity in acute lymphoblastic leukemia (ALL).
Tyler W. Jenkins, Jacquelyn Elise Fitzgerald, Jieun Park, Addison M. Wilson, Kristy L. Berry, Keith S. Wong, Walid A. Houry, Irene Lee, Andrey V. Maksimenko, Peter R. Panizzi, Yulia Y. Maxuitenko, Matthew Shane Loop, Amit K. Mitra, Alexei F. Kisselev   +13 more
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Epigenetic regulator genes direct lineage switching in MLL/AF4 leukaemia [PDF]

The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukaemia resulting in poor clinical outcomes due to resistance towards chemo- and immuno-therapies.
Tirtakusuma, Ricky, Szoltysek, Katarzyna, Milne, Paul, Grinev, Vasily, Ptasinska, Anetta, Chin, Paulynn Suyin, Meyer, Claus, Nakjang, Sirintra, Hehir-Kwa, Jayne Y, Williamson, Daniel, Cauchy, Pierre, Keane, Peter, Assi, Salam a, Ashtiani, Minoo, Kellaway, Sophie G., Imperato, Maria R, Vogiatzi, Fotini, Schweighart-James, Elizabeth K, Lin, Shan, Wunderlich, Mark, Stutterheim, Janine, Komkov, Alexander, Zerkalenkova Elena, PhD, Evans, Paul, McNeill, Hesta Varey, Elder, Alex, Martínez-Soria, Natalia, Fordham, Sarah E, Shi, Yuzhe, Russell, Lisa J, Pal, Deepali, Smith, Alexandra G, Kingsbury, Zoya, Becq, Jennifer, Eckert, Cornelia, Haas, Oskar A, Carey, Peter, Bailey, Simon, Skinner, Roderick, Miakova, Natalia, Collin, Matthew, Bigley, Venetia, Haniffa, Muzlifah, Marschalek, Rolf, Harrison, Christine J, Cargo, Catherine A, Schewe, Denis Martin, Olshanskaya, Yulia, Thirman, Michael J., Cockerill, Peter N   +49 more
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Establishment of MLL/AF4 Transgenic Mice with the Phenotype of Lymphoblastic Leukemia or Lymphoma

Journal of Nippon Medical School, 2013
Tamai, Hayato, Inokuchi, Koiti
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Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene

Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene
Mixed-lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy-related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL-AF4 fusion transcript. MLL-AF4 is derived from
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The role of Menin in transcriptional regulation of MLL-AF4 and NPM1-mutated leukaemia

Inhibition of the protein-protein interaction between Menin and Mixed Lineage Leukaemia 1 (MLL, also known as KMT2A) is emerging as a promising targeted treatment for specific high risk acute leukaemias. Menin is essential in leukaemias with rearrangements of the MLL1 gene or mutations in NPM1 — two subtypes with distinct genetic backgrounds.
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