Results 121 to 130 of about 16,106 (168)

CRISPR/Cas9-mediated t(4;11) translocation in human hematopoietic stem/precursor cells demonstrates plasticity to differentiate into either the myeloid or lymphoid lineage. [PDF]

Leukemia
Benz T, Larghero P, Meyer C, Hanewald T, Brüggmann D, Hentrich AE, Louwen F, Marschalek R.   +7 more
europepmc   +1 more source

A small molecule inhibitor of RNA-binding protein IGF2BP3 shows anti-leukemic activity. [PDF]

Haematologica
Jaiswal AK, Scherer GM, Thaxton ML, Sorrentino JP, Yuen C, Mehta MM, Sharma G, Lin TL, Tran TM, Cohen A, Ritter AJ, Kotecha RS, Sanford JR, Damoiseaux RD, Garg NK, Rao DS.   +15 more
europepmc   +1 more source

IGF2BP3 inhibition: another home run for RNA-binding protein targeting in hematological malignancies. [PDF]

Haematologica
Penalva LOF.
europepmc   +1 more source

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia. [PDF]

Front Pediatr
Zhu Z, Yan J.
europepmc   +1 more source

Menin maintains enhancer-promoter interactions in a leukemia-specific manner

Sharlandjieva V, Chahrour C, Lassen FH, Hamley JC, Damianou A, Denny N, Smith AL, Hester SS, Vendrell I, Stam RW, Konopleva M, Roy A, Davies JOJ, Crump NT, Kessler BM, Milne TA.   +15 more
europepmc   +1 more source

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]

Leukemia Research, 2011
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish Kumar, John H Kersey
exaly   +3 more sources

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A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features.

Blood, 2023
The cellular ontogeny and location of the MLL-breakpoint influence the capacity of MLL-edited CD34+ HSPCs to initiate pro-B-ALL, and recapitulate the molecular features of MLL-AF4+ infant B-ALL patients.
C. Bueno, R. Torres-Ruiz, Talía Velasco-Hernández, O. Molina, P. Petazzi, A. Martínez-Moreno, Virginia C. Rodríguez-Cortez, M. Vinyoles, S. Cantilena, Owen Williams, Nerea Vega-García, S. Rodríguez-Perales, J. Segovia, O. Quintana-Bustamante, A. Roy, Claus Meyer, R. Marschalek, Alastair L. Smith, T. Milne, Mario F Fraga, J. R. Tejedor, Pablo Menéndez   +21 more
semanticscholar   +1 more source

Gene Expression Network and Circ_0008012 Promote Progression in MLL/AF4 Positive Acute Lymphoblastic Leukemia.

Recent Patents on Anti-Cancer Drug Discovery, 2022
BACKGROUND Acute lymphoblastic leukemia with MLL/AF4 rearrangement remains a major hurdle to improving outcomes. Gene network and circRNAs have been found to participate in tumorigenesis, while their roles in leukemia still need to be explored.
Yanlai Tang, Jiahui Su, Jie Luo, Li-dan Zhang, L. Zheng, C. Liang, Li-na Wang, Yu Li, Zhongcheng Fan, Dan-Ping Huang, Panpan Sun, Zhenhua Luo, N. Qi, Jing-Jing Lan, Xiao-Li Zhang, Li-Bin Huang, Xue-Qun Luo   +16 more
semanticscholar   +1 more source

Methylation-mediated repression of microRNA-143 enhances MLL–AF4 oncogene expression [PDF]

Oncogene, 2011
Fusion proteins containing the amino terminus of mixed lineage leukemia (MLL) are common in acute lymphoblastic leukemia (ALL) due to translocations. The MLL-AF4 fusion protein is generated by the translocation t(4;11)(q21;q23), and t(4;11)-positive ALL patients (MLL-AF4 ALL), have a notoriously poorer prognosis compared with patients with other MLL ...
Zheng D, Gao L
exaly   +3 more sources

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias [PDF]

Cancer Cell, 2008
We created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Gene expression profile analysis of the ALL cells demonstrated significant overlap with human MLL-rearranged ALL.
Madeleine Lemieux, Adrian P Bracken, Andrei Krivtsov   +2 more
exaly   +3 more sources