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A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology [PDF]

Oncogene, 2006
MLL-AF4 fusion is the most common consequence of chromosomal translocations in infant leukaemia and is associated with a poor prognosis. MLL-AF4 is thought to be required in haematopoietic stem cells to elicit leukaemia and may be involved in tumour phenotype specification as it is only found in B-cell tumours in humans.
Markus Metzler, Terence Rabbitts, Mark Arends   +2 more
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Alert and sniffy-nosed about Mll-AF4?

Blood, 2006
Comment on Chen et al, page [669][1] A report from the Kersey laboratory documents the long-awaited successful establishment of a murine model for leukemogenesis by the Mll-AF4 fusion gene. The MLL gene is notorious for its promiscuous fusion with multiple alternative partner genes in leukemia,
Mel Greaves, C. W. Eric So
openaire   +1 more source

MLL-AF4 Gene Fusions in Normal Newborns

Blood, 1999
To the Editor: Uckun et al[1][1] have reported that bona fide in-frame fusion MLL-AF4 fusion sequences are detectable, using a sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method, in around 25% of normal fetal bone marrow and liver samples and in 1 of 6 infant ...
M.-H. Kim-Rouille, A. MacGregor, L.M. Wiedemann, M.F. Greaves, C. Navarrete   +4 more
openaire   +1 more source

The ongoing conundrum of MLL-AF4 driven leukemogenesis

Blood, 2013
In this issue of Blood, Bueno and colleagues explore the developmental impact, as well as the transforming capacity, of the mixed-lineage leukemia (MLL)–AF4 fusion protein in combination with activation of FMS-like tyrosine receptor 3 (FLT3) in human embryonic stem cells (hESCs ...
openaire   +2 more sources

Detection of MLL/AF4 Recombination by PCR Technique

1996
The molecular analysis of chromosomal translocations occurring in human leukemias revealed the existence of newly formed fusion genes. The balanced translocation between chromosomes 4 and 11, for instance, results in a new MLL/AF4 gene as the AF4 gene at chromosomal region 4q21 is juxtaposed next to the part of the MLL gene (also called ALL-1 or HRX ...
A. Borkhardt, R. Repp, J. Hammermann, S. Brettreich, R. Gossen, E. Haupt, J. Harbott, F. Lampert   +7 more
openaire   +1 more source

GREM1 promotes leukemic survival via PI3K/AKT signaling in infant MLL-AF4-positive B-ALL.

Experimental Hematology
Infant B-cell acute lymphoblastic leukemia (B-ALL) harboring the KMT2A-AFF1 (MLL-AF4) fusion is associated with aggressive clinical behavior and poor outcomes, yet the molecular regulators that sustain leukemic cell survival in this high-risk subtype ...
Xiaotian Liu, Youjian Zhang, S. Hua, Xuejun Shao, Lei Yin   +4 more
semanticscholar   +1 more source

Pediatric Acute Megakaryoblastic Leukemia with T(4;11) (Q21;Q23)/MLL-AF4 Fusion Transcript: A Case Report

Annals of Nursing Research & Practice, 2022
Acute Megakaryoblastic Leukemia (AMKL) is a rare and biologically heterogenous subtype of Acute Myeloid Leukemia (AML) with a diverse cytogenetic profile. Mix-lineage leukemia (MLL) rearrangements are commonly found in infant Acute Lymphoblastic Leukemia
Li Zhang, Hanyi Hou, Xiurong Gao, M. Yan, Yanmei Li, Yiqian Wang   +5 more
semanticscholar   +1 more source

Acute megakaryoblastic leukemia in a child with the MLL‐AF4 fusion gene

European Journal of Haematology, 2009
AbstractMixed‐lineage leukemia (MLL) rearrangements are commonly observed in childhood acute lymphoblastic and myeloid leukemia, as well as therapy‐related leukemia. However, the occurrence of MLL rearrangements in acute megakaryoblastic leukemia (AMKL) is very rare. We report a pediatric case of AMKL with the MLL‐AF4 fusion transcript.
Junko, Takita, Ai, Motomura, Katsuyoshi, Koh, Kohmei, Ida, Tomohiko, Taki, Yasuhide, Hayashi, Takashi, Igarashi   +6 more
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No Evidence for MLL/AF4 Expression in Normal Cord Blood Samples

Blood, 1999
To the Editor: In a recent issue of Blood, Uckun et al[1][1] reported a high frequency of the MLL/AF4 expression not only among infant patients with acute lymphoblastic leukemia (ALL) but also among children older than 1 year (12 out of 127) at the diagnosis of the disease.
J. Trka, J. Zuna, O. Hrušák, K. Michalová, K. Mužı́ková, M. Kalinová, J. Starý   +6 more
openaire   +1 more source

Identification of Genes Abnormally Expressed in Human MLL-AF4 Leukemia.

Blood, 2006
Abstract The t(4;11)(q21;q23) translocation is a hallmark of infant acute lymphoblastic leukemia (ALL), which results in the fusion of the MLL gene on chromosome 11 and the AF4 gene on chromosome 4. MLL-AF4 fusion is the most common consequence of chromosomal translocations in infant leukemia and is associated with a poor prognosis.
Jianjun Chen, Janet D. Rowley, San Ming Wang, Michael J. Thirman, Theodore G. Karrison, Sanggyu Lee, Yanming Zhang, Masha Kocherginsky, Mary Beth Neilly, Nimanthi Jayathilaka, Roger T. Luo, Zejuan Li, Miao Sun, Shuangli Mi   +13 more
openaire   +1 more source