Results 141 to 150 of about 16,106 (168)

Targeting the unique barcode of MLL/AF4

Klinische Pädiatrie, 2022
R Cameron, L Swart, M Rasouli, O Heidenreich   +3 more
openaire   +1 more source

MLL-AF4 and FLT3 Activation Synergize To Induce Multi Step Leukemogenesis.

Blood, 2006
Abstract Acute lymphoblastic leukemia (ALL) expressing mixed-lineage leukemia (MLL)- AF4, the fusion product of t(4;11)(q21;q23), respond poorly to chemotherapy and have poor prognosis. MLL was required in normal hematopoietic proliferation and differentiation through Hox gene regulation. AF4 is a serine/proline rich nuclear protein with
Kazuo Dan, Takashi Shimada, Mituharu Inami, Naoya Uchida, Yoshio Mitamura, Kazuhiro Sawaguchi, Hideki Hanawa, Koiti Inokuchi, Hiroki Yamaguchi   +8 more
openaire   +1 more source

Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A.

Recent Patents on Anti-Cancer Drug Discovery
BACKGROUND Chromosomal rearrangements involving the Mixed lineage leukemia (MLL) gene are observed in acute leukemia (AL) patients, which have poor prognosis, especially in infants.
Xueming Li, Fenglian Zhang, Yu Ke, Hongmin Liu, Zhenbo Hu, Liuya Wei   +5 more
semanticscholar   +1 more source

The T(4;11) Fusion Protein MLL/AF4 Regulates TERT Expression

Blood, 2008
Abstract About 50% of all infants suffering from acute lymphoblastic leukaemia (ALL) show the translocation t(4;11)(q21;q23) which creates the fusion genes MLL/AF4 and AF4/MLL. This reciprocal translocation identifies a therapy resistant form of leukaemia with a poor prognosis.
Johann Greil, Olaf Heidenreich, Patricia Garrido Castro, Maria Thomas, Andreas Gessner   +4 more
openaire   +1 more source

3105 – IMPACT OF DACH1 DOWNREGULATION ON MLL-AF4 INFANT LEUKEMOGENESIS

Experimental Hematology, 2022
Helene Jakobczyk, Giuseppina Camiolo, Camille Malouf, Eric Antunes, Katrin Ottersbach   +4 more
openaire   +1 more source

Epigenetic modifiers direct lineage switch in MLL-AF4 leukemia

Klinische Pädiatrie, 2022
K Szoltysek, R Tirtakusuma, M Ashtiani, S Nakjang, V V Grinev, J Hehir-Kwa, EK Schweighart, S Bomken, O Heidenreich   +8 more
openaire   +1 more source

[Targeted regulation of mll-af4 fusion gene by miR-142-3p].

Zhongguo shi yan xue ye xue za zhi, 2011
In order to analyze the possible epigenetic regulation mechanism of mll-af4 gene expression and find the possible microRNA regulating mll-af4 gene expression, targetscan software was used to analyze potential microRNA target sites in 3'-UTR of mll-af4. 3'-UTR fragment of mll-af4 was amplified by PCR.
Li-Ping, Dou, Yong-Hui, Li, Cheng-Wang, Xu, Li-Li, Wang, Li, Yu   +4 more
openaire   +1 more source

Small changes in the MLL-AF4 fusion protein make a difference

Klinische Pädiatrie, 2020
A Siemund, E Kowarz, R Marschalek
openaire   +1 more source

Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells

bioRxiv
Shivani Rajhansa, N. Crump, Hwei Minn Khoo, Yavor K Bozhilov, Paul E. Brennan, Oleg Fedorov, Cassandra Adams, Gillian Farnie, Thomas A. Milne, Adam C. Wilkinson   +9 more
semanticscholar   +1 more source

The role of the DACH family of nuclear proteins in MLL-AF4-associated infant leukaemia

Klinische Pädiatrie, 2023
H. Jakobczyk, K. Ottersbach
semanticscholar   +1 more source