Results 201 to 210 of about 25,228 (245)

The MLL PHD Fingers of MLL Block MLL Fusion Protein Mediated Transformation.

Blood, 2007
Abstract Mixed Lineage Leukemia (MLL) is a histone H3K4 methyltransferase that is rearranged in both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). MLL is required for the maintenance of Hox gene expression. Deregulation of Hox genes by MLL fusion proteins, which fuse MLL in frame to one of over 50 different ...
Andrew G. Muntean, Jay L. Hess
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Abstract 3849: The partial tandem duplication of Mll (Mll PTD) is a gain-of-function in the absence of Mll wildtype (Mll WT) in adult mouse hematopoiesis.

Cancer Research, 2013
Abstract Cytogenetically normal acute myeloid leukemia (CN AML) patients with a MLL PTD have a poor prognosis compared to CN AML patients with MLL WT. We previously reported that the MLL WT gene in MLL PTD+ CN AML is epigenetically silenced.
Nicholas A. Zorko, Daniel A. Yanes, W. Courtland Lewis, Daniel L. Brook, Kelsie M. Bernot, Ronald F. Siebenaler, Susan P. Whitman, Elshafa H. Ahmed, Kathleen K. McConnell, John Nemer, Patricia Ernst, Gang Huang, Guido Marcucci, Michael A. Caligiuri   +13 more
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MLL: exploring the methylome

Blood, 2010
In this issue of Blood, Schafer and colleagues report their findings on MLL-r infant ALL. 1 They examined global promoter methylation in infants and found hypermethylation in cases with MLL-r ALL compared with both the normal and non-MLL-r ALL cases. When treating MLL-r cell lines with decitabine, they observed a reexpression of silenced genes and a ...
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The role of MLL in hematopoiesis and leukemia

Current Opinion in Hematology, 2002
The MLL gene, also called HRX or ALL-1, was originally identified as a recurrent chromosomal translocation in particular subtypes of acute lymphocytic leukemia (ALL) and acute myelogenous leukemia (AML). Reciprocal rearrangements of the MLL gene are most common in infant ALL and secondary AML.
Patricia, Ernst, Jing, Wang, Stanley J, Korsmeyer   +2 more
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Mechanisms of Transformation by MLL

Critical Reviews in Eukaryotic Gene Expression, 2004
Rearrangements of the mixed-lineage leukemia gene MLL1 (MLL, HRX, ALL1), the human homologue of the Drosophila gene trithorax, are associated with aggressive acute leukemias in both children and adults. Transformation by rearranged forms of MLL1, including in-frame fusion proteins, partial tandem duplications, and amplification of MLL1 through ...
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A case of acute myelogenous leukemia with MLL–AF10 fusion caused by insertion of 5′ MLL into 10p12, with concurrent 3′ MLL deletion

Cancer Genetics and Cytogenetics, 2006
Structural abnormalities involving the mixed-lineage leukemia (MLL) gene on 11q23 have been associated with hematological malignancies. The rearrangement of MLL occurs during translocations and insertions involving a variety of genes on the partner chromosome.
Kazuyuki, Matsuda, Eiko, Hidaka, Fumihiro, Ishida, Kazuyoshi, Yamauchi, Hideki, Makishima, Toshiro, Ito, Takefumi, Suzuki, Eri, Imagawa, Kenji, Sano, Tsutomu, Katsuyama, Hiroyoshi, Ota   +10 more
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Targeting Menin-MLL Interaction to Inhibit MLL Fusion Oncoproteins in Leukemia

Blood, 2011
Abstract Abstract 2497 Chromosomal translocations that affect the MLL (Mixed Lineage Leukemia) proto-oncogene occur in aggressive acute leukemias, both in children and adults. Fusion of MLL to one of more than 50 partner genes results in generation of the MLL fusion oncoprotein, which upregulates expression of HOX genes ...
Jolanta Grembecka, Shihan He, Aibin Shi, Trupta Purohit, Andrew G. Muntean, Xiaoqin Li, Thomas Hartley, Duxin Sun, Jay L. Hess, Tomasz Cierpicki   +9 more
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Performance of the MLL-IonCatcher

Review of Scientific Instruments, 2006
The MLL-IonCatcher is a new setup for the thermalization of fusion-evaporation reaction products in highly pure helium with subsequent extraction of the stopped, singly charged ions. The setup consists of a buffer-gas stopping cell and a radio frequency quadrupole (RFQ)-based extraction system and is placed at the Tandem accelerator facility of the MLL
J. B. Neumayr, P. G. Thirolf, D. Habs, S. Heinz, V. S. Kolhinen, M. Sewtz, J. Szerypo   +6 more
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Analyzing the MLL Recombinome.

Blood, 2004
Abstract Acute leukemias are frequently associated with specific chromosomal translocations of the human MLL gene. In general, MLL translocations define a distinct disease entity that needs to be diagnosed with precision to facilitate rapid clinical decisions.
Claus Meyer, Bjoern Schneider, Martin Reichel, Sieglinde Angermuller, Susanne Schnittger, Claudia Schoch, Mieke W.J.C. Jansen, Jacques J.. M. van Dongen, Rob Pieters, Oskar Haas, Sabine Strehl, Theo Dingermann, Thomas Klingebiel, Rolf Marschalek   +13 more
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