Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]
, 2011 Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong +4 more
core +1 more source
Reduced cardiovascular mortality in oral 1 -hydroxy vitamin D3 users in a haemodialysis population; do CRP and MMP markers of inflammation reflect this finding? [PDF]
, 2005 Barbara J. Boucher
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Advanced Healthcare Materials, EarlyView.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]
, 2016 BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki +9 more
core +2 more sources
The Anti-inflammatory and Anti-apoptotic Role of Crocin against Expression of MMp-9, TIMP-1, MCP-1, Caspase-3, PPARα in Heart Tissue, and Metamorphoses of MicroRNA 188 in Hyperhomocysteinemic Rats [PDF]
, 2019 Samy Hussein +3 more
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Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective α-sulfone hydroxamates
Bioorganic & Medicinal Chemistry Letters, 2010 A series of phenyl piperidine alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13, are dual-sparing of MMP-1 and MMP-14 (MT1-MMP) and exhibit oral bioavailability in rats.
Stephen A, Kolodziej +12 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Simvastatin mitigates placental hypoperfusion in OAPS by ameliorating abnormal uteromaternal hemodynamics and enhancing trophoblast invasion via optimized endothelial cell interactions under pathological shear stress, as evidenced by results from a placenta‐on‐a‐chip platform.
Hongli Liu +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He +10 more
wiley +1 more source
Journal of Hepatocellular CarcinomaPriyanka,1,2 Somdutt Mujwar,3 Ram Bharti,1,2 Thakur Gurjeet Singh,3 Neeraj Khatri1,2 1IMTech Centre for Animal Resources & Experimentation (iCARE), CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India; 2Academy of Scientific ...
Priyanka +4 more
doaj
Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth
Advanced Healthcare Materials, EarlyView.To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs +6 more
wiley +1 more source