Results 131 to 140 of about 390,769 (349)

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

Journal of Cell Biology, 2000
Laminin-5 (Ln-5) is an extracellular matrix substrate for cell adhesion and migration, which is found in many epithelial basement membranes. Mechanisms eliciting migration on Ln-5 need to be elucidated because of their relevance to tissue remodeling and ...
N. Koshikawa, G. Giannelli, V. Cirulli, Kaoru Miyazaki, V. Quaranta   +4 more
semanticscholar   +1 more source

MMP-2 quantification using advanced software-based digital image analysis.

, 2017
Image analysis was performed using a pixel classifier based on Bayesian classification. The classifier was trained to identify nuclei (green color) and measure MMP-2 intensity in a three μm perimeter around the nuclei (turquoise color).
Simon K. Hermansen (3778771), Bjarne W. Kristensen (3778777), Mia D. Sørensen (3778774), Rahimsan K. Ramachandran (3778768), Charlotte Aaberg-Jessen (2889320)   +4 more
core   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Determination of Minimum Miscibility Pressure by Analytical Method [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2007
The analytical theory of one dimensional, dispersion free miscible displacement of oil by injection gas with nc component has shown that: the MMP is the lowest pressure at which any one of the initial oil, injection gas or crossover key tie lines becomes
Ali Reza Motaleby Nedjad, Mohsen Vafaie Sefti, Hassan Naderi   +2 more
doaj  

MMP-9 expression according to molecular subtype.

, 2018
MMP-9 expression according to molecular subtype.
Sukjoong Oh (5683670), Seong Sik Bang (5683661), Young Hwan Kim (132717), Sung-Im Do (5683667), Young Ha Oh (5683664), Jungho Yang (5683643), Mi Jung Kwon (5683673), Dong-Hoon Kim (5683649), Seoung Wan Chae (229254), Byoung Kwan Son (5683652), Young Chan Wi (5683658), Kyueng-Whan Min (5683646), Kyoung Min Moon (5683655)   +12 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

2,2’- Bipyridine Derivatives Exert Anticancer Effects by Inducing Apoptosis in Hepatocellular Carcinoma (HepG2) Cells

Journal of Hepatocellular Carcinoma
Priyanka,1,2 Somdutt Mujwar,3 Ram Bharti,1,2 Thakur Gurjeet Singh,3 Neeraj Khatri1,2 1IMTech Centre for Animal Resources & Experimentation (iCARE), CSIR-Institute of Microbial Technology (CSIR-IMTECH), Chandigarh, 160036, India; 2Academy of Scientific ...
Priyanka, Mujwar S, Bharti R, Singh TG, Khatri N   +4 more
doaj  

Matriksimetalloproteinaasit hengitysteiden bakteeri-infektion indikaattoreina : Trakeobronkiaalihuuhtelunesteen MMP-2-ja MMP-9-aktiivisuudet vasikan luonnollisissa pasteurella-infektioissa

, 2001
Tutkimuksessa selvitettiin vasikoiden trakeobronkiaalihuuhtelunäytteissä esiintyviä MMP-2- ja MMP-9-tasoja sekä hengitysteiden Pasteurella-infektion yhteydessä MMP-aktiivisuuksissa tapahtuvia muutoksia.
Eskelinen, Ulla
core