Results 141 to 150 of about 240,787 (310)

MMP-9 mRNA upregulation is accompanied by robust MMP-9 promoter demethylation in hippocampi of epileptic patients.

open access: yes, 2016
(A) MMP-9 mRNA expression is substantially increased in the hippocampi of adult and pediatric epileptic patients. For each RT-qPCR analysis, equal amounts of RNA samples isolated from control, epileptic adult and pediatric patients’ hippocampi were used.
Joanna Wilemska (3141396)   +14 more
core   +1 more source

Integrated Single‐Cell and Spatial Analysis Reveals a Metabolic‐Immune Axis Driving Aortic Dissection

open access: yesAdvanced Science, EarlyView.
Single‐cell and spatial profiling of 110 human thoracic aortic samples reveals a stromal–immune circuit driving aortic dissection. An elastin‐rich fibroblast subset is depleted with age and markedly reduced in disease, weakening aortic wall integrity.
Jing Tao   +25 more
wiley   +1 more source

A hybrid framework for lithium-ion battery SOH estimation under partial charging based on ICA reconstruction

open access: yesEnergy Conversion and Management: X
Accurate estimation of the State of Health (SOH) of lithium-ion batteries is essential for ensuring safety, extending service life, and enabling predictive maintenance in energy storage applications. Peak features from Incremental Capacity Analysis (ICA)
Qi Zhao   +5 more
doaj   +1 more source

Plasma Levels of Matrilysins (MMP-7 and MMP-26) and Stromelysins (MMP-3 and MMP-10) in Diagnosis of Endometrial Cancer Patients

open access: yesInternational Journal of Molecular Sciences
Metalloproteinases (MMPs) play a significant role in cancer pathogenesis. We investigated the levels of MMP-7, MMP-26, MMP-3, and MMP-10 in comparison with the levels of a tumor marker (CA125) in the plasma of postmenopausal patients in early stages of endometrial cancer (EC) compared with control groups: patients with benign lesions (myoma uteri) and ...
Ewa Gacuta   +6 more
openaire   +3 more sources

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng   +10 more
wiley   +1 more source

Activity of MMP-2, MMP-8 and MMP-9 in serum as a marker of progression of alcoholic liver disease in people from Lublin Region, eastern Poland

open access: yes, 2015
In alcoholic liver cirrhosis, normal liver cells are replaced by scar tissue (fibrosis). Liver fibrosis is a dynamic process in which activated hepatic stellate cells are involved in the synthesis of matrix proteins and the regulation of matrix ...
Anna Boguszewska-Czubara   +11 more
core   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

open access: yesAdvanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang   +23 more
wiley   +1 more source

Pathological MMP singularities as αp-quotients

open access: yesForum of Mathematics, Sigma
We construct pathological examples of MMP singularities in every positive characteristic using quotients by $\alpha _p$ -actions. In particular, we obtain non- $S_3$ terminal singularities, as well as locally stable (respectively stable ...
Quentin Posva
doaj   +1 more source

Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice

open access: yesAdvanced Science, EarlyView.
Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li   +5 more
wiley   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

open access: yesAdvanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak   +19 more
wiley   +1 more source

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